Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group

Søren W Pedersen, Christopher J Armishaw, Kristian Strømgaard

    4 Citationer (Scopus)

    Abstract

    The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.
    OriginalsprogEngelsk
    TitelPeptide synthesis and applications
    Antal sider16
    Vol/bind1047
    ForlagHumana Press
    Publikationsdato2013
    Sider65-80
    ISBN (Elektronisk)978-1-62703-544-6
    DOI
    StatusUdgivet - 2013
    NavnMethods in Molecular Biology
    ISSN1064-3745

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