Synthesis of antimicrobial peptoids

Paul Robert Hansen; Jens Munk

doi:10.1007/978-1-62703-544-6_11

Synthesis of antimicrobial peptoids

6 Citations (Scopus)

Abstract

Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N ^α -amide nitrogen instead of the C ^α -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases. In recent years, peptoids have attracted attention as new potential antibiotics against multiresistant bacteria. Here we describe the submonomer solid-phase synthesis of an antimicrobial peptoid, H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH₂.

Original language	English
Title of host publication	Peptide synthesis and applications
Volume	1047
Publication date	2013
Edition	2nd
Pages	151-159
ISBN (Electronic)	978-1-62703-543-9
DOIs	https://doi.org/10.1007/978-1-62703-544-6_11
Publication status	Published - 2013

Series	Methods in Molecular Biology
ISSN	1064-3745

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10.1007/978-1-62703-544-6_11

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AB - Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N α -amide nitrogen instead of the C α -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases. In recent years, peptoids have attracted attention as new potential antibiotics against multiresistant bacteria. Here we describe the submonomer solid-phase synthesis of an antimicrobial peptoid, H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH2.

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VL - 1047

T3 - Methods in Molecular Biology

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BT - Peptide synthesis and applications

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Synthesis of antimicrobial peptoids

Abstract

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