Synthesis of antimicrobial peptoids

Paul Robert Hansen; Jens Munk

doi:10.1007/978-1-62703-544-6_11

Synthesis of antimicrobial peptoids

6 Citationer (Scopus)

Abstract

Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N ^α -amide nitrogen instead of the C ^α -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases. In recent years, peptoids have attracted attention as new potential antibiotics against multiresistant bacteria. Here we describe the submonomer solid-phase synthesis of an antimicrobial peptoid, H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH₂.

Originalsprog	Engelsk
Titel	Peptide synthesis and applications
Vol/bind	1047
Publikationsdato	2013
Udgave	2nd
Sider	151-159
ISBN (Elektronisk)	978-1-62703-543-9
DOI	https://doi.org/10.1007/978-1-62703-544-6_11
Status	Udgivet - 2013

Navn	Methods in Molecular Biology
ISSN	1064-3745

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10.1007/978-1-62703-544-6_11

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AB - Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N α -amide nitrogen instead of the C α -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases. In recent years, peptoids have attracted attention as new potential antibiotics against multiresistant bacteria. Here we describe the submonomer solid-phase synthesis of an antimicrobial peptoid, H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH2.

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Synthesis of antimicrobial peptoids

Abstract

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