Synthesis and thermotropic phase behavior of four glycoglycerolipids

Wouter Frederik Johan Hogendorf; Vivien Jagalski; Thomas Günther-Pomorski; Mikael Bols; Marite Cardenas Gomez; Christian Marcus Pedersen

doi:10.3390/molecules181113546

Synthesis and thermotropic phase behavior of four glycoglycerolipids

Wouter Frederik Johan Hogendorf, Vivien Jagalski, Thomas Günther-Pomorski, Mikael Bols, Marite Cardenas Gomez, Christian Marcus Pedersen

5 Citations (Scopus)

Abstract

Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.

Original language	English
Journal	Molecules
Volume	18
Issue number	11
Pages (from-to)	13546-13573
Number of pages	28
ISSN	1420-3049
DOIs	https://doi.org/10.3390/molecules181113546
Publication status	Published - Nov 2013

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AU - Hogendorf, Wouter Frederik Johan

AU - Jagalski, Vivien

AU - Günther-Pomorski, Thomas

AU - Bols, Mikael

AU - Cardenas Gomez, Marite

AU - Pedersen, Christian Marcus

PY - 2013/11

Y1 - 2013/11

N2 - Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.

AB - Four glycoglycerolipids with different head groups have been synthesized and their physicochemical properties studied. The lengths of the head groups from a mono-saccharide to a trisaccharide, in addition to the anomeric stereochemistry for the smaller glycoglycerolipids, have been modified. The synthesis has been optimized to avoid glycerol epimerization and to allow up-scaling. The physicochemical properties of the glycoglycerolipids were studied and a strong de-mixing of the gel-phase, depending on the head-group, was observed.

U2 - 10.3390/molecules181113546

DO - 10.3390/molecules181113546

M3 - Journal article

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SN - 1420-3049

VL - 18

SP - 13546

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JO - Molecules

JF - Molecules

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Synthesis and thermotropic phase behavior of four glycoglycerolipids

Abstract

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