Syndecans and cell adhesion.

J R Couchman; L Chen; A Woods

Syndecans and cell adhesion.

Nutritional Immunology

118 Citations (Scopus)

Abstract

Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.

Original language	English
Book series	International Review of Cytology
Volume	207
Pages (from-to)	113-50
Number of pages	37
ISSN	0074-7696
Publication status	Published - 2001

Cite this

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title = "Syndecans and cell adhesion.",

abstract = "Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.",

author = "Couchman, {J R} and L Chen and A Woods",

note = "Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Glycosaminoglycans; Humans; Membrane Glycoproteins; Models, Molecular; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Proteoglycans; Sequence Alignment; Signal Transduction; Syndecans",

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AU - Couchman, J R

AU - Chen, L

AU - Woods, A

N1 - Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Glycosaminoglycans; Humans; Membrane Glycoproteins; Models, Molecular; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Proteoglycans; Sequence Alignment; Signal Transduction; Syndecans

PY - 2001

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N2 - Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.

AB - Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.

M3 - Journal article

C2 - 11352265

SN - 1937-6448

VL - 207

SP - 113

EP - 150

JO - International Review of Cell and Molecular Biology

JF - International Review of Cell and Molecular Biology

ER -

Syndecans and cell adhesion.

Abstract

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