TY - JOUR
T1 - Syndecans and cell adhesion.
AU - Couchman, J R
AU - Chen, L
AU - Woods, A
N1 - Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Glycosaminoglycans; Humans; Membrane Glycoproteins; Models, Molecular; Molecular Sequence Data; Phylogeny; Protein Structure, Tertiary; Proteoglycans; Sequence Alignment; Signal Transduction; Syndecans
PY - 2001
Y1 - 2001
N2 - Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.
AB - Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research.
M3 - Journal article
C2 - 11352265
SN - 1937-6448
VL - 207
SP - 113
EP - 150
JO - International Review of Cell and Molecular Biology
JF - International Review of Cell and Molecular Biology
ER -