Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Anette M. Hammerum; Ulrik S. Justesen; Mette Pinholt; Louise Roer; Hülya Kaya; Peder Worning; Sanne Nygaard; Michael Kemp; Marianne Engell Clausen; Karen Leth Nielsen; Jurgita Samulioniené; Mona Kjærsgaard; Claus Østergaard; John Coia; Turid Snekloth Søndergaard; Shahin Gaini; Kristian Schønning; Henrik Westh; Henrik Hasman; Barbara Juliane Holzknecht

doi:10.2807/1560-7917.ES.2019.24.34.1900503

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Anette M. Hammerum, Ulrik S. Justesen, Mette Pinholt, Louise Roer, Hülya Kaya, Peder Worning, Sanne Nygaard, Michael Kemp, Marianne Engell Clausen, Karen Leth Nielsen, Jurgita Samulioniené, Mona Kjærsgaard, Claus Østergaard, John Coia, Turid Snekloth Søndergaard, Shahin Gaini, Kristian Schønning, Henrik Westh, Henrik Hasman, Barbara Juliane Holzknecht

Department of Clinical Medicine

9 Citations (Scopus)

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Abstract

We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.

Original language	English
Journal	Eurosurveillance
Volume	24
Issue number	34
Pages (from-to)	1-5
ISSN	1025-496X
DOIs	https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503
Publication status	Published - 22 Aug 2019

Keywords

Enterococci
MLST
vanA
vanB
VRE
VVE

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Hammerum, A. M., Justesen, U. S., Pinholt, M., Roer, L., Kaya, H., Worning, P., Nygaard, S., Kemp, M., Clausen, M. E., Nielsen, K. L., Samulioniené, J., Kjærsgaard, M., Østergaard, C., Coia, J., Søndergaard, T. S., Gaini, S., Schønning, K., Westh, H., Hasman, H., & Holzknecht, B. J. (2019). Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019. Eurosurveillance, 24(34), 1-5. https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019. / Hammerum, Anette M.; Justesen, Ulrik S.; Pinholt, Mette et al.
In: Eurosurveillance, Vol. 24, No. 34, 22.08.2019, p. 1-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Hammerum, AM, Justesen, US, Pinholt, M, Roer, L, Kaya, H, Worning, P, Nygaard, S, Kemp, M, Clausen, ME, Nielsen, KL, Samulioniené, J, Kjærsgaard, M, Østergaard, C, Coia, J, Søndergaard, TS, Gaini, S, Schønning, K , Westh, H, Hasman, H & Holzknecht, BJ 2019, 'Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019', Eurosurveillance, vol. 24, no. 34, pp. 1-5. https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503

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title = "Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019",

abstract = "We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.",

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AU - Justesen, Ulrik S.

AU - Pinholt, Mette

AU - Roer, Louise

AU - Kaya, Hülya

AU - Worning, Peder

AU - Nygaard, Sanne

AU - Kemp, Michael

AU - Clausen, Marianne Engell

AU - Nielsen, Karen Leth

AU - Samulioniené, Jurgita

AU - Kjærsgaard, Mona

AU - Østergaard, Claus

AU - Coia, John

AU - Søndergaard, Turid Snekloth

AU - Gaini, Shahin

AU - Schønning, Kristian

AU - Westh, Henrik

AU - Hasman, Henrik

AU - Holzknecht, Barbara Juliane

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N2 - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.

AB - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.

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KW - MLST

KW - vanA

KW - vanB

KW - VRE

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DO - 10.2807/1560-7917.ES.2019.24.34.1900503

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ER -

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Abstract

Keywords

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