Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Anette M. Hammerum; Ulrik S. Justesen; Mette Pinholt; Louise Roer; Hülya Kaya; Peder Worning; Sanne Nygaard; Michael Kemp; Marianne Engell Clausen; Karen Leth Nielsen; Jurgita Samulioniené; Mona Kjærsgaard; Claus Østergaard; John Coia; Turid Snekloth Søndergaard; Shahin Gaini; Kristian Schønning; Henrik Westh; Henrik Hasman; Barbara Juliane Holzknecht

doi:10.2807/1560-7917.ES.2019.24.34.1900503

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

Anette M. Hammerum, Ulrik S. Justesen, Mette Pinholt, Louise Roer, Hülya Kaya, Peder Worning, Sanne Nygaard, Michael Kemp, Marianne Engell Clausen, Karen Leth Nielsen, Jurgita Samulioniené, Mona Kjærsgaard, Claus Østergaard, John Coia, Turid Snekloth Søndergaard, Shahin Gaini, Kristian Schønning, Henrik Westh, Henrik Hasman, Barbara Juliane Holzknecht

Institut for Klinisk Medicin

9 Citationer (Scopus)

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Abstract

We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.

Originalsprog	Engelsk
Tidsskrift	Eurosurveillance
Vol/bind	24
Udgave nummer	34
Sider (fra-til)	1-5
ISSN	1025-496X
DOI	https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503
Status	Udgivet - 22 aug. 2019

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10.2807/1560-7917.ES.2019.24.34.1900503Licens: CC BY

eurosurv-24-34-1Forlagets udgivne version, 400 KBLicens: CC BY

Citationsformater

Hammerum, A. M., Justesen, U. S., Pinholt, M., Roer, L., Kaya, H., Worning, P., Nygaard, S., Kemp, M., Clausen, M. E., Nielsen, K. L., Samulioniené, J., Kjærsgaard, M., Østergaard, C., Coia, J., Søndergaard, T. S., Gaini, S., Schønning, K., Westh, H., Hasman, H., & Holzknecht, B. J. (2019). Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019. Eurosurveillance, 24(34), 1-5. https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019. / Hammerum, Anette M.; Justesen, Ulrik S.; Pinholt, Mette et al.
I: Eurosurveillance, Bind 24, Nr. 34, 22.08.2019, s. 1-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hammerum, AM, Justesen, US, Pinholt, M, Roer, L, Kaya, H, Worning, P, Nygaard, S, Kemp, M, Clausen, ME, Nielsen, KL, Samulioniené, J, Kjærsgaard, M, Østergaard, C, Coia, J, Søndergaard, TS, Gaini, S, Schønning, K , Westh, H, Hasman, H & Holzknecht, BJ 2019, 'Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019', Eurosurveillance, bind 24, nr. 34, s. 1-5. https://doi.org/10.2807/1560-7917.ES.2019.24.34.1900503

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title = "Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019",

abstract = "We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.",

keywords = "Enterococci, MLST, vanA, vanB, VRE, VVE",

author = "Hammerum, {Anette M.} and Justesen, {Ulrik S.} and Mette Pinholt and Louise Roer and H{\"u}lya Kaya and Peder Worning and Sanne Nygaard and Michael Kemp and Clausen, {Marianne Engell} and Nielsen, {Karen Leth} and Jurgita Samulionien{\'e} and Mona Kj{\ae}rsgaard and Claus {\O}stergaard and John Coia and S{\o}ndergaard, {Turid Snekloth} and Shahin Gaini and Kristian Sch{\o}nning and Henrik Westh and Henrik Hasman and Holzknecht, {Barbara Juliane}",

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AU - Hammerum, Anette M.

AU - Justesen, Ulrik S.

AU - Pinholt, Mette

AU - Roer, Louise

AU - Kaya, Hülya

AU - Worning, Peder

AU - Nygaard, Sanne

AU - Kemp, Michael

AU - Clausen, Marianne Engell

AU - Nielsen, Karen Leth

AU - Samulioniené, Jurgita

AU - Kjærsgaard, Mona

AU - Østergaard, Claus

AU - Coia, John

AU - Søndergaard, Turid Snekloth

AU - Gaini, Shahin

AU - Schønning, Kristian

AU - Westh, Henrik

AU - Hasman, Henrik

AU - Holzknecht, Barbara Juliane

PY - 2019/8/22

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N2 - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.

AB - We describe clonal shifts in vanA Enterococcus faecium isolates from clinical samples obtained from patients in Denmark from 2015 to the first quarter (Q1) of 2019. During Q1 2019, the vancomycin-variable enterococci (VVE) ST1421-CT1134 vanA E. faecium became the most dominant vanA E. faecium clone and has spread to all five regions in Denmark. Among 174 E. faecium isolates with vanA, vanB or vanA/vanB genes in Q1 2019, 44% belonged to this type. We describe the clonal shift for vanA Enterococcus faecium during the last 4 years and the national spread of a vancomycin-variable vanA E. faecium ST1421-CT1134 clone in Denmark. The aim is to highlight the importance of using molecular methods for detecting vancomycin-variable enterococci (VVE), and to alert other countries about this emerging nosocomial clone.

KW - Enterococci

KW - MLST

KW - vanA

KW - vanB

KW - VRE

KW - VVE

U2 - 10.2807/1560-7917.ES.2019.24.34.1900503

DO - 10.2807/1560-7917.ES.2019.24.34.1900503

M3 - Journal article

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SN - 1025-496X

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ER -

Surveillance of vancomycin-resistant enterococci reveals shift in dominating clones and national spread of a vancomycin-variable vanA Enterococcus faecium ST1421-CT1134 clone, Denmark, 2015 to March 2019

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