Surveillance for Secure Differentiation

William B Hamilton; Joshua M Brickman

doi:10.1016/j.stem.2016.12.011

Surveillance for Secure Differentiation

William B Hamilton, Joshua M Brickman

Stem Cell and developmental Biology - early embryonic lineage specification Lab

1 Citation (Scopus)

Abstract

The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem Cell, Wang et al. (2017) investigate how converging Wnt and Nodal signals promote mesendoderm through a p53, Wnt3 feed-forward loop, pointing to a mechanism by which cells gauge time and fitness during differentiation.

Original language	English
Journal	Cell Stem Cell
Volume	20
Issue number	1
Pages (from-to)	3-5
Number of pages	3
DOIs	https://doi.org/10.1016/j.stem.2016.12.011
Publication status	Published - 5 Jan 2017

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10.1016/j.stem.2016.12.011

http://www.cell.com/article/S1934590916304672/pdf

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title = "Surveillance for Secure Differentiation",

abstract = "The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem Cell, Wang et al. (2017) investigate how converging Wnt and Nodal signals promote mesendoderm through a p53, Wnt3 feed-forward loop, pointing to a mechanism by which cells gauge time and fitness during differentiation.",

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AB - The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem Cell, Wang et al. (2017) investigate how converging Wnt and Nodal signals promote mesendoderm through a p53, Wnt3 feed-forward loop, pointing to a mechanism by which cells gauge time and fitness during differentiation.

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Surveillance for Secure Differentiation

Abstract

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