Surface-bound microgels - From physicochemical properties to biomedical applications

Lina Nyström; Martin Malmsten

doi:10.1016/j.cis.2016.11.003

Surface-bound microgels - From physicochemical properties to biomedical applications

22 Citations (Scopus)

Abstract

Microgels offer robust and facile approaches for surface modification, as well as opportunities to introduce biological functionality by loading such structures with bioactive agents, e.g., in the context of drug delivery, functional biomaterials, and biosensors. As such, they provide a versatile approach for the design of surfaces with pre-determined characteristics compared to more elaborate bottom-up approaches, such as layer-by-layer deposition and surface-initiated polymerization. In the present overview, properties of surface-bound microgels are discussed, ranging from physical adsorption and covalent grafting in dilute systems, to directed self-assembly, multilayer structures, and composites, as well as loading an release of drugs and other cargo molecules into/from such systems, and biomedical applications of these.

Original language	English
Journal	Advances in Colloid and Interface Science
Volume	238
Pages (from-to)	88-104
Number of pages	17
ISSN	0001-8686
DOIs	https://doi.org/10.1016/j.cis.2016.11.003
Publication status	Published - 1 Dec 2016

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abstract = "Microgels offer robust and facile approaches for surface modification, as well as opportunities to introduce biological functionality by loading such structures with bioactive agents, e.g., in the context of drug delivery, functional biomaterials, and biosensors. As such, they provide a versatile approach for the design of surfaces with pre-determined characteristics compared to more elaborate bottom-up approaches, such as layer-by-layer deposition and surface-initiated polymerization. In the present overview, properties of surface-bound microgels are discussed, ranging from physical adsorption and covalent grafting in dilute systems, to directed self-assembly, multilayer structures, and composites, as well as loading an release of drugs and other cargo molecules into/from such systems, and biomedical applications of these.",

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AB - Microgels offer robust and facile approaches for surface modification, as well as opportunities to introduce biological functionality by loading such structures with bioactive agents, e.g., in the context of drug delivery, functional biomaterials, and biosensors. As such, they provide a versatile approach for the design of surfaces with pre-determined characteristics compared to more elaborate bottom-up approaches, such as layer-by-layer deposition and surface-initiated polymerization. In the present overview, properties of surface-bound microgels are discussed, ranging from physical adsorption and covalent grafting in dilute systems, to directed self-assembly, multilayer structures, and composites, as well as loading an release of drugs and other cargo molecules into/from such systems, and biomedical applications of these.

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JO - Advances in Colloid and Interface Science

JF - Advances in Colloid and Interface Science

ER -

Surface-bound microgels - From physicochemical properties to biomedical applications

Abstract

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