TY - JOUR
T1 - Surface-bound microgels - From physicochemical properties to biomedical applications
AU - Nyström, Lina
AU - Malmsten, Martin
N1 - Copyright © 2016 Elsevier B.V. All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Microgels offer robust and facile approaches for surface modification, as well as opportunities to introduce biological functionality by loading such structures with bioactive agents, e.g., in the context of drug delivery, functional biomaterials, and biosensors. As such, they provide a versatile approach for the design of surfaces with pre-determined characteristics compared to more elaborate bottom-up approaches, such as layer-by-layer deposition and surface-initiated polymerization. In the present overview, properties of surface-bound microgels are discussed, ranging from physical adsorption and covalent grafting in dilute systems, to directed self-assembly, multilayer structures, and composites, as well as loading an release of drugs and other cargo molecules into/from such systems, and biomedical applications of these.
AB - Microgels offer robust and facile approaches for surface modification, as well as opportunities to introduce biological functionality by loading such structures with bioactive agents, e.g., in the context of drug delivery, functional biomaterials, and biosensors. As such, they provide a versatile approach for the design of surfaces with pre-determined characteristics compared to more elaborate bottom-up approaches, such as layer-by-layer deposition and surface-initiated polymerization. In the present overview, properties of surface-bound microgels are discussed, ranging from physical adsorption and covalent grafting in dilute systems, to directed self-assembly, multilayer structures, and composites, as well as loading an release of drugs and other cargo molecules into/from such systems, and biomedical applications of these.
U2 - 10.1016/j.cis.2016.11.003
DO - 10.1016/j.cis.2016.11.003
M3 - Journal article
C2 - 27865424
SN - 0001-8686
VL - 238
SP - 88
EP - 104
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
ER -