Supplemental folic acid in pregnancy and childhood cancer risk

Jan Helge Seglem Mortensen; Nina Øyen; Tatiana Fomina; Mads Melbye; Steinar Tretli; Stein Emil Vollset; Tone Bjørge

doi:10.1038/bjc.2015.446

Supplemental folic acid in pregnancy and childhood cancer risk

Jan Helge Seglem Mortensen, Nina Øyen, Tatiana Fomina, Mads Melbye, Steinar Tretli, Stein Emil Vollset, Tone Bjørge^*

^*Corresponding author for this work

Department of Clinical Medicine

16 Citations (Scopus)

Abstract

Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.

Original language	English
Journal	British Journal of Cancer
Volume	114
Pages (from-to)	71-75
Number of pages	5
ISSN	0007-0920
DOIs	https://doi.org/10.1038/bjc.2015.446
Publication status	Published - 2016

Keywords

childhood cancer
cohort study
folic acid supplementation
pregnancy

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/bjc.2015.446

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@article{966a40f3c4c347b5bb8032ba0826eba5,

title = "Supplemental folic acid in pregnancy and childhood cancer risk",

abstract = "Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.",

keywords = "childhood cancer, cohort study, folic acid supplementation, pregnancy",

author = "Mortensen, {Jan Helge Seglem} and Nina {\O}yen and Tatiana Fomina and Mads Melbye and Steinar Tretli and Vollset, {Stein Emil} and Tone Bj{\o}rge",

year = "2016",

doi = "10.1038/bjc.2015.446",

language = "English",

volume = "114",

pages = "71--75",

journal = "British Journal of Cancer",

issn = "0007-0920",

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TY - JOUR

T1 - Supplemental folic acid in pregnancy and childhood cancer risk

AU - Mortensen, Jan Helge Seglem

AU - Øyen, Nina

AU - Fomina, Tatiana

AU - Melbye, Mads

AU - Tretli, Steinar

AU - Vollset, Stein Emil

AU - Bjørge, Tone

PY - 2016

Y1 - 2016

N2 - Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.

AB - Background:We investigated the association between supplemental folic acid in pregnancy and childhood cancer in a nation-wide study of 687 406 live births in Norway, 1999-2010, and 799 children diagnosed later with cancer.Methods:Adjusted hazard ratios (HRs) compared cancer risk in children by approximated periconceptional folic acid levels (folic acid tablets and multivitamins (0.6 mg), only folic acid (0.4 mg), only multivitamins (0.2 mg)) and cancer risk in unexposed.Results:Any folic acid levels were not associated with leukemia (e.g., high-level folic acid HR 1.25; 95% CI 0.89-1.76, P Trend 0.20), lymphoma (HR 0.96; 95% CI 0.42-2.21, P Trend 0.51), central nervous system tumours (HR 0.68; 95% CI 0.42-1.10, P Trend 0.32), neuroblastoma (HR 1.05; 95% CI 0.53-2.06, P Trend 0.85), Wilms' tumour (HR 1.16; 95% CI 0.52-2.58, P Trend 0.76), or soft-tissue tumours (HR 0.77; 95% CI 0.34-1.75, P Trend 0.90).Conclusions:Folic acid supplementation was not associated with risk of major childhood cancers.

KW - childhood cancer

KW - cohort study

KW - folic acid supplementation

KW - pregnancy

U2 - 10.1038/bjc.2015.446

DO - 10.1038/bjc.2015.446

M3 - Journal article

C2 - 26757423

AN - SCOPUS:84954349446

SN - 0007-0920

VL - 114

SP - 71

EP - 75

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Supplemental folic acid in pregnancy and childhood cancer risk

Abstract

Keywords

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