64Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with 68Ga-DOTATOC in 60 Patients

Catarina Malmberg; Rasmus Sejersten Ripa; Camilla Bardram Johnbeck; Ulrich Knigge; Seppo W Langer; Jann Mortensen; Peter Sandor Oturai; Annika Loft; Anne Mette Hag; Andreas Kjær

doi:10.2967/jnumed.115.161216

⁶⁴Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with ⁶⁸Ga-DOTATOC in 60 Patients

Catarina Malmberg, Rasmus Sejersten Ripa, Camilla Bardram Johnbeck, Ulrich Knigge, Seppo W Langer, Jann Mortensen, Peter Sandor Oturai, Annika Loft, Anne Mette Hag, Andreas Kjær

46 Citations (Scopus)

Abstract

The somatostatin receptor subtype 2 is expressed on macrophages, an abundant cell type in the atherosclerotic plaque. Visualization of somatostatin receptor subtype 2, for oncologic purposes, is frequently made using the DOTA-derived somatostatin analogs DOTATOC or DOTATATE for PET. We aimed to compare the uptake of the PET tracers ⁶⁸Ga-DOTATOC and ⁶⁴Cu-DOTATATE in large arteries, in the assessment of atherosclerosis by noninvasive imaging technique, combining PET and CT. Further, the correlation of uptake and cardiovascular risk factors was investigated. Methods: Sixty consecutive patients with neuroendocrine tumors underwent both ⁶⁸Ga-DOTATOC and ⁶⁴Cu-DOTATATE PET/CT scans, in random order. For each scan, the maximum and mean standardized uptake values (SUVs) were calculated in 5 arterial segments. In addition, the blood-pool-corrected target-to-background ratio was calculated. Uptake of the tracers was correlated with cardiovascular risk factors collected from medical records. Results: We found detectable uptake of both tracers in all arterial segments studied. Uptake of ⁶⁴Cu-DOTATATE was significantly higher than ⁶⁸Ga-DOTATOC in the vascular regions both when calculated as maximum and mean uptake. There was a significant association between Framingham risk score and the overall maximum uptake of ⁶⁴Cu-DOTATATE using SUV (r = 0.4; P = 0.004) as well as target-to-background ratio (r = 0.3; P = 0.04), whereas no association was found with ⁶⁸Ga-DOTATOC. The association of risk factors and maximum SUV of ⁶⁴Cu-DOTATATE was found driven by body mass index, smoking, diabetes, and coronary calcium score (P < 0.001, P = 0.01, P = 0.005, and P = 0.03, respectively). Conclusion: In a series of oncologic patients, vascular uptake of ⁶⁸Ga-DOTATOC and ⁶⁴Cu-DOTATATE was found, with highest uptake of the latter. Uptake of ⁶⁴Cu-DOTATATE, but not of ⁶⁸Ga-DOTATOC, was correlated with cardiovascular risk factors, suggesting a potential role for ⁶⁴Cu-DOTATATE in the assessment of atherosclerosis.

Original language	English
Journal	Journal of Nuclear Medicine
Volume	56
Issue number	12
Pages (from-to)	1895-900
Number of pages	6
ISSN	0161-5505
DOIs	https://doi.org/10.2967/jnumed.115.161216
Publication status	Published - 1 Dec 2015

Keywords

Adult
Aged
Aged, 80 and over
Aorta
Arteries
Atherosclerosis
Body Mass Index
Calcium
Cardiovascular Diseases
Coronary Vessels
Diabetes Mellitus
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Neuroendocrine Tumors
Octreotide
Organometallic Compounds
Positron-Emission Tomography
Radiopharmaceuticals
Risk Factors
Smoking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Malmberg, C., Ripa, R. S., Johnbeck, C. B., Knigge, U., Langer, S. W., Mortensen, J., Oturai, P. S., Loft, A., Hag, A. M., & Kjær, A. (2015). ⁶⁴Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with ⁶⁸Ga-DOTATOC in 60 Patients. Journal of Nuclear Medicine, 56(12), 1895-900. https://doi.org/10.2967/jnumed.115.161216

⁶⁴Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with ⁶⁸Ga-DOTATOC in 60 Patients. / Malmberg, Catarina; Ripa, Rasmus Sejersten; Johnbeck, Camilla Bardram et al.
In: Journal of Nuclear Medicine, Vol. 56, No. 12, 01.12.2015, p. 1895-900.

Research output: Contribution to journal › Journal article › Research › peer-review

Malmberg, C, Ripa, RS, Johnbeck, CB, Knigge, U , Langer, SW , Mortensen, J, Oturai, PS, Loft, A, Hag, AM & Kjær, A 2015, '⁶⁴Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with ⁶⁸Ga-DOTATOC in 60 Patients', Journal of Nuclear Medicine, vol. 56, no. 12, pp. 1895-900. https://doi.org/10.2967/jnumed.115.161216

@article{ce5bd3f953f74f47aebebd54de9511c6,

title = "64Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with 68Ga-DOTATOC in 60 Patients",

abstract = "The somatostatin receptor subtype 2 is expressed on macrophages, an abundant cell type in the atherosclerotic plaque. Visualization of somatostatin receptor subtype 2, for oncologic purposes, is frequently made using the DOTA-derived somatostatin analogs DOTATOC or DOTATATE for PET. We aimed to compare the uptake of the PET tracers 68Ga-DOTATOC and 64Cu-DOTATATE in large arteries, in the assessment of atherosclerosis by noninvasive imaging technique, combining PET and CT. Further, the correlation of uptake and cardiovascular risk factors was investigated. Methods: Sixty consecutive patients with neuroendocrine tumors underwent both 68Ga-DOTATOC and 64Cu-DOTATATE PET/CT scans, in random order. For each scan, the maximum and mean standardized uptake values (SUVs) were calculated in 5 arterial segments. In addition, the blood-pool-corrected target-to-background ratio was calculated. Uptake of the tracers was correlated with cardiovascular risk factors collected from medical records. Results: We found detectable uptake of both tracers in all arterial segments studied. Uptake of 64Cu-DOTATATE was significantly higher than 68Ga-DOTATOC in the vascular regions both when calculated as maximum and mean uptake. There was a significant association between Framingham risk score and the overall maximum uptake of 64Cu-DOTATATE using SUV (r = 0.4; P = 0.004) as well as target-to-background ratio (r = 0.3; P = 0.04), whereas no association was found with 68Ga-DOTATOC. The association of risk factors and maximum SUV of 64Cu-DOTATATE was found driven by body mass index, smoking, diabetes, and coronary calcium score (P < 0.001, P = 0.01, P = 0.005, and P = 0.03, respectively). Conclusion: In a series of oncologic patients, vascular uptake of 68Ga-DOTATOC and 64Cu-DOTATATE was found, with highest uptake of the latter. Uptake of 64Cu-DOTATATE, but not of 68Ga-DOTATOC, was correlated with cardiovascular risk factors, suggesting a potential role for 64Cu-DOTATATE in the assessment of atherosclerosis.",

keywords = "Adult, Aged, Aged, 80 and over, Aorta, Arteries, Atherosclerosis, Body Mass Index, Calcium, Cardiovascular Diseases, Coronary Vessels, Diabetes Mellitus, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuroendocrine Tumors, Octreotide, Organometallic Compounds, Positron-Emission Tomography, Radiopharmaceuticals, Risk Factors, Smoking",

author = "Catarina Malmberg and Ripa, {Rasmus Sejersten} and Johnbeck, {Camilla Bardram} and Ulrich Knigge and Langer, {Seppo W} and Jann Mortensen and Oturai, {Peter Sandor} and Annika Loft and Hag, {Anne Mette} and Andreas Kj{\ae}r",

note = "{\textcopyright} 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",

year = "2015",

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doi = "10.2967/jnumed.115.161216",

language = "English",

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TY - JOUR

T1 - 64Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors

T2 - Head-to-Head Comparison with 68Ga-DOTATOC in 60 Patients

AU - Malmberg, Catarina

AU - Ripa, Rasmus Sejersten

AU - Johnbeck, Camilla Bardram

AU - Knigge, Ulrich

AU - Langer, Seppo W

AU - Mortensen, Jann

AU - Oturai, Peter Sandor

AU - Loft, Annika

AU - Hag, Anne Mette

AU - Kjær, Andreas

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The somatostatin receptor subtype 2 is expressed on macrophages, an abundant cell type in the atherosclerotic plaque. Visualization of somatostatin receptor subtype 2, for oncologic purposes, is frequently made using the DOTA-derived somatostatin analogs DOTATOC or DOTATATE for PET. We aimed to compare the uptake of the PET tracers 68Ga-DOTATOC and 64Cu-DOTATATE in large arteries, in the assessment of atherosclerosis by noninvasive imaging technique, combining PET and CT. Further, the correlation of uptake and cardiovascular risk factors was investigated. Methods: Sixty consecutive patients with neuroendocrine tumors underwent both 68Ga-DOTATOC and 64Cu-DOTATATE PET/CT scans, in random order. For each scan, the maximum and mean standardized uptake values (SUVs) were calculated in 5 arterial segments. In addition, the blood-pool-corrected target-to-background ratio was calculated. Uptake of the tracers was correlated with cardiovascular risk factors collected from medical records. Results: We found detectable uptake of both tracers in all arterial segments studied. Uptake of 64Cu-DOTATATE was significantly higher than 68Ga-DOTATOC in the vascular regions both when calculated as maximum and mean uptake. There was a significant association between Framingham risk score and the overall maximum uptake of 64Cu-DOTATATE using SUV (r = 0.4; P = 0.004) as well as target-to-background ratio (r = 0.3; P = 0.04), whereas no association was found with 68Ga-DOTATOC. The association of risk factors and maximum SUV of 64Cu-DOTATATE was found driven by body mass index, smoking, diabetes, and coronary calcium score (P < 0.001, P = 0.01, P = 0.005, and P = 0.03, respectively). Conclusion: In a series of oncologic patients, vascular uptake of 68Ga-DOTATOC and 64Cu-DOTATATE was found, with highest uptake of the latter. Uptake of 64Cu-DOTATATE, but not of 68Ga-DOTATOC, was correlated with cardiovascular risk factors, suggesting a potential role for 64Cu-DOTATATE in the assessment of atherosclerosis.

AB - The somatostatin receptor subtype 2 is expressed on macrophages, an abundant cell type in the atherosclerotic plaque. Visualization of somatostatin receptor subtype 2, for oncologic purposes, is frequently made using the DOTA-derived somatostatin analogs DOTATOC or DOTATATE for PET. We aimed to compare the uptake of the PET tracers 68Ga-DOTATOC and 64Cu-DOTATATE in large arteries, in the assessment of atherosclerosis by noninvasive imaging technique, combining PET and CT. Further, the correlation of uptake and cardiovascular risk factors was investigated. Methods: Sixty consecutive patients with neuroendocrine tumors underwent both 68Ga-DOTATOC and 64Cu-DOTATATE PET/CT scans, in random order. For each scan, the maximum and mean standardized uptake values (SUVs) were calculated in 5 arterial segments. In addition, the blood-pool-corrected target-to-background ratio was calculated. Uptake of the tracers was correlated with cardiovascular risk factors collected from medical records. Results: We found detectable uptake of both tracers in all arterial segments studied. Uptake of 64Cu-DOTATATE was significantly higher than 68Ga-DOTATOC in the vascular regions both when calculated as maximum and mean uptake. There was a significant association between Framingham risk score and the overall maximum uptake of 64Cu-DOTATATE using SUV (r = 0.4; P = 0.004) as well as target-to-background ratio (r = 0.3; P = 0.04), whereas no association was found with 68Ga-DOTATOC. The association of risk factors and maximum SUV of 64Cu-DOTATATE was found driven by body mass index, smoking, diabetes, and coronary calcium score (P < 0.001, P = 0.01, P = 0.005, and P = 0.03, respectively). Conclusion: In a series of oncologic patients, vascular uptake of 68Ga-DOTATOC and 64Cu-DOTATATE was found, with highest uptake of the latter. Uptake of 64Cu-DOTATATE, but not of 68Ga-DOTATOC, was correlated with cardiovascular risk factors, suggesting a potential role for 64Cu-DOTATATE in the assessment of atherosclerosis.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aorta

KW - Arteries

KW - Atherosclerosis

KW - Body Mass Index

KW - Calcium

KW - Cardiovascular Diseases

KW - Coronary Vessels

KW - Diabetes Mellitus

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Middle Aged

KW - Neuroendocrine Tumors

KW - Octreotide

KW - Organometallic Compounds

KW - Positron-Emission Tomography

KW - Radiopharmaceuticals

KW - Risk Factors

KW - Smoking

U2 - 10.2967/jnumed.115.161216

DO - 10.2967/jnumed.115.161216

M3 - Journal article

C2 - 26429961

SN - 0161-5505

VL - 56

SP - 1895

EP - 1900

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

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ER -