TY - JOUR
T1 - 64Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors
T2 - Head-to-Head Comparison with 68Ga-DOTATOC in 60 Patients
AU - Malmberg, Catarina
AU - Ripa, Rasmus Sejersten
AU - Johnbeck, Camilla Bardram
AU - Knigge, Ulrich
AU - Langer, Seppo W
AU - Mortensen, Jann
AU - Oturai, Peter Sandor
AU - Loft, Annika
AU - Hag, Anne Mette
AU - Kjær, Andreas
N1 - © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The somatostatin receptor subtype 2 is expressed on macrophages, an abundant cell type in the atherosclerotic plaque. Visualization of somatostatin receptor subtype 2, for oncologic purposes, is frequently made using the DOTA-derived somatostatin analogs DOTATOC or DOTATATE for PET. We aimed to compare the uptake of the PET tracers 68Ga-DOTATOC and 64Cu-DOTATATE in large arteries, in the assessment of atherosclerosis by noninvasive imaging technique, combining PET and CT. Further, the correlation of uptake and cardiovascular risk factors was investigated. Methods: Sixty consecutive patients with neuroendocrine tumors underwent both 68Ga-DOTATOC and 64Cu-DOTATATE PET/CT scans, in random order. For each scan, the maximum and mean standardized uptake values (SUVs) were calculated in 5 arterial segments. In addition, the blood-pool-corrected target-to-background ratio was calculated. Uptake of the tracers was correlated with cardiovascular risk factors collected from medical records. Results: We found detectable uptake of both tracers in all arterial segments studied. Uptake of 64Cu-DOTATATE was significantly higher than 68Ga-DOTATOC in the vascular regions both when calculated as maximum and mean uptake. There was a significant association between Framingham risk score and the overall maximum uptake of 64Cu-DOTATATE using SUV (r = 0.4; P = 0.004) as well as target-to-background ratio (r = 0.3; P = 0.04), whereas no association was found with 68Ga-DOTATOC. The association of risk factors and maximum SUV of 64Cu-DOTATATE was found driven by body mass index, smoking, diabetes, and coronary calcium score (P < 0.001, P = 0.01, P = 0.005, and P = 0.03, respectively). Conclusion: In a series of oncologic patients, vascular uptake of 68Ga-DOTATOC and 64Cu-DOTATATE was found, with highest uptake of the latter. Uptake of 64Cu-DOTATATE, but not of 68Ga-DOTATOC, was correlated with cardiovascular risk factors, suggesting a potential role for 64Cu-DOTATATE in the assessment of atherosclerosis.
AB - The somatostatin receptor subtype 2 is expressed on macrophages, an abundant cell type in the atherosclerotic plaque. Visualization of somatostatin receptor subtype 2, for oncologic purposes, is frequently made using the DOTA-derived somatostatin analogs DOTATOC or DOTATATE for PET. We aimed to compare the uptake of the PET tracers 68Ga-DOTATOC and 64Cu-DOTATATE in large arteries, in the assessment of atherosclerosis by noninvasive imaging technique, combining PET and CT. Further, the correlation of uptake and cardiovascular risk factors was investigated. Methods: Sixty consecutive patients with neuroendocrine tumors underwent both 68Ga-DOTATOC and 64Cu-DOTATATE PET/CT scans, in random order. For each scan, the maximum and mean standardized uptake values (SUVs) were calculated in 5 arterial segments. In addition, the blood-pool-corrected target-to-background ratio was calculated. Uptake of the tracers was correlated with cardiovascular risk factors collected from medical records. Results: We found detectable uptake of both tracers in all arterial segments studied. Uptake of 64Cu-DOTATATE was significantly higher than 68Ga-DOTATOC in the vascular regions both when calculated as maximum and mean uptake. There was a significant association between Framingham risk score and the overall maximum uptake of 64Cu-DOTATATE using SUV (r = 0.4; P = 0.004) as well as target-to-background ratio (r = 0.3; P = 0.04), whereas no association was found with 68Ga-DOTATOC. The association of risk factors and maximum SUV of 64Cu-DOTATATE was found driven by body mass index, smoking, diabetes, and coronary calcium score (P < 0.001, P = 0.01, P = 0.005, and P = 0.03, respectively). Conclusion: In a series of oncologic patients, vascular uptake of 68Ga-DOTATOC and 64Cu-DOTATATE was found, with highest uptake of the latter. Uptake of 64Cu-DOTATATE, but not of 68Ga-DOTATOC, was correlated with cardiovascular risk factors, suggesting a potential role for 64Cu-DOTATATE in the assessment of atherosclerosis.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aorta
KW - Arteries
KW - Atherosclerosis
KW - Body Mass Index
KW - Calcium
KW - Cardiovascular Diseases
KW - Coronary Vessels
KW - Diabetes Mellitus
KW - Female
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Male
KW - Middle Aged
KW - Neuroendocrine Tumors
KW - Octreotide
KW - Organometallic Compounds
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Risk Factors
KW - Smoking
U2 - 10.2967/jnumed.115.161216
DO - 10.2967/jnumed.115.161216
M3 - Journal article
C2 - 26429961
SN - 0161-5505
VL - 56
SP - 1895
EP - 1900
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 12
ER -
