Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

T. Wienecke; J.M. Hansen; J. Petersen; K.S. Olsen; M. Ashina; P. Tfelt-Hansen

Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

T. Wienecke, J.M. Hansen, J. Petersen, K.S. Olsen, M. Ashina, P. Tfelt-Hansen

3 Citations (Scopus)

Abstract

Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system
Udgivelsesdato: 2008/10

Original language	English
Journal	Cephalalgia
Volume	28
Issue number	10
Pages (from-to)	1081-1085
Number of pages	4
ISSN	0333-1024
Publication status	Published - 2008

Cite this

@article{337dbb00f75d11ddbf70000ea68e967b,

title = "Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects",

abstract = "Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system Udgivelsesdato: 2008/10",

author = "T. Wienecke and J.M. Hansen and J. Petersen and K.S. Olsen and M. Ashina and P. Tfelt-Hansen",

note = "Times Cited: 0ArticleEnglishWienecke, TUniv Copenhagen, Fac Hlth Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, DenmarkCited References Count: 18348QBBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD",

year = "2008",

language = "English",

volume = "28",

pages = "1081--1085",

journal = "Cephalalgia",

issn = "0333-1024",

publisher = "SAGE Publications",

number = "10",

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TY - JOUR

T1 - Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

AU - Wienecke, T.

AU - Hansen, J.M.

AU - Petersen, J.

AU - Olsen, K.S.

AU - Ashina, M.

AU - Tfelt-Hansen, P.

N1 - Times Cited: 0ArticleEnglishWienecke, TUniv Copenhagen, Fac Hlth Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, DenmarkCited References Count: 18348QBBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD

PY - 2008

Y1 - 2008

N2 - Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system Udgivelsesdato: 2008/10

AB - Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system Udgivelsesdato: 2008/10

M3 - Journal article

SN - 0333-1024

VL - 28

SP - 1081

EP - 1085

JO - Cephalalgia

JF - Cephalalgia

IS - 10

ER -