Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

T. Wienecke; J.M. Hansen; J. Petersen; K.S. Olsen; M. Ashina; P. Tfelt-Hansen

Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

T. Wienecke, J.M. Hansen, J. Petersen, K.S. Olsen, M. Ashina, P. Tfelt-Hansen

3 Citationer (Scopus)

Abstract

Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system
Udgivelsesdato: 2008/10

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	28
Udgave nummer	10
Sider (fra-til)	1081-1085
Antal sider	4
ISSN	0333-1024
Status	Udgivet - 2008

Citationsformater

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title = "Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects",

abstract = "Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system Udgivelsesdato: 2008/10",

author = "T. Wienecke and J.M. Hansen and J. Petersen and K.S. Olsen and M. Ashina and P. Tfelt-Hansen",

note = "Times Cited: 0ArticleEnglishWienecke, TUniv Copenhagen, Fac Hlth Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, DenmarkCited References Count: 18348QBBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD",

year = "2008",

language = "English",

volume = "28",

pages = "1081--1085",

journal = "Cephalalgia, Supplement",

issn = "0800-1952",

publisher = "SAGE Publications",

number = "10",

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TY - JOUR

T1 - Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

AU - Wienecke, T.

AU - Hansen, J.M.

AU - Petersen, J.

AU - Olsen, K.S.

AU - Ashina, M.

AU - Tfelt-Hansen, P.

N1 - Times Cited: 0ArticleEnglishWienecke, TUniv Copenhagen, Fac Hlth Sci, Glostrup Hosp, Danish Headache Ctr, Copenhagen, DenmarkCited References Count: 18348QBBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD

PY - 2008

Y1 - 2008

N2 - Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system Udgivelsesdato: 2008/10

AB - Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O-2 difference (AVDO(2)). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO(2), we measured the AVDO(2) in the external jugular vein in healthy subjects. We also measured the AVDO(2) in the internal jugular and cubital veins. There were no changes in AVDO(2) after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system Udgivelsesdato: 2008/10

M3 - Journal article

SN - 0800-1952

VL - 28

SP - 1081

EP - 1085

JO - Cephalalgia, Supplement

JF - Cephalalgia, Supplement

IS - 10

ER -