Sulfonimidamides in Medicinal and Agricultural Chemistry

Praveen K Chinthakindi; Tricia Naicker; Niranjan Thota; Thavendran Govender; Hendrik G Kruger; Per I Arvidsson

doi:10.1002/anie.201610456

Sulfonimidamides in Medicinal and Agricultural Chemistry

Praveen K Chinthakindi, Tricia Naicker, Niranjan Thota, Thavendran Govender, Hendrik G Kruger, Per I Arvidsson

58 Citations (Scopus)

Abstract

The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.

Original language	English
Journal	Angewandte Chemie (International ed. in English)
Volume	56
Issue number	15
Pages (from-to)	4100-4109
Number of pages	10
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201610456
Publication status	Published - 3 Apr 2017
Externally published	Yes

Keywords

Journal Article
Review

Access to Document

10.1002/anie.201610456

Cite this

@article{ad969a5abfa94b6ca411115e1d8dba15,

title = "Sulfonimidamides in Medicinal and Agricultural Chemistry",

abstract = "The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.",

keywords = "Journal Article, Review",

author = "Chinthakindi, {Praveen K} and Tricia Naicker and Niranjan Thota and Thavendran Govender and Kruger, {Hendrik G} and Arvidsson, {Per I}",

note = "{\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2017",

month = apr,

day = "3",

doi = "10.1002/anie.201610456",

language = "English",

volume = "56",

pages = "4100--4109",

journal = "Angewandte Chemie (International ed. in English)",

issn = "1433-7851",

publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",

number = "15",

}

TY - JOUR

T1 - Sulfonimidamides in Medicinal and Agricultural Chemistry

AU - Chinthakindi, Praveen K

AU - Naicker, Tricia

AU - Thota, Niranjan

AU - Govender, Thavendran

AU - Kruger, Hendrik G

AU - Arvidsson, Per I

PY - 2017/4/3

Y1 - 2017/4/3

N2 - The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.

AB - The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.

KW - Journal Article

KW - Review

U2 - 10.1002/anie.201610456

DO - 10.1002/anie.201610456

M3 - Review

C2 - 27958674

SN - 1433-7851

VL - 56

SP - 4100

EP - 4109

JO - Angewandte Chemie (International ed. in English)

JF - Angewandte Chemie (International ed. in English)

IS - 15

ER -

Sulfonimidamides in Medicinal and Agricultural Chemistry

Abstract

Keywords

Access to Document

Fingerprint

Cite this