Sulfonimidamides in Medicinal and Agricultural Chemistry

Praveen K Chinthakindi; Tricia Naicker; Niranjan Thota; Thavendran Govender; Hendrik G Kruger; Per I Arvidsson

doi:10.1002/anie.201610456

Sulfonimidamides in Medicinal and Agricultural Chemistry

Praveen K Chinthakindi, Tricia Naicker, Niranjan Thota, Thavendran Govender, Hendrik G Kruger, Per I Arvidsson

58 Citationer (Scopus)

Abstract

The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.

Originalsprog	Engelsk
Tidsskrift	Angewandte Chemie (International ed. in English)
Vol/bind	56
Udgave nummer	15
Sider (fra-til)	4100-4109
Antal sider	10
ISSN	1433-7851
DOI	https://doi.org/10.1002/anie.201610456
Status	Udgivet - 3 apr. 2017
Udgivet eksternt	Ja

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10.1002/anie.201610456

Citationsformater

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AU - Chinthakindi, Praveen K

AU - Naicker, Tricia

AU - Thota, Niranjan

AU - Govender, Thavendran

AU - Kruger, Hendrik G

AU - Arvidsson, Per I

PY - 2017/4/3

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AB - The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.

KW - Journal Article

KW - Review

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DO - 10.1002/anie.201610456

M3 - Review

C2 - 27958674

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JF - Angewandte Chemie (International ed. in English)

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ER -

Sulfonimidamides in Medicinal and Agricultural Chemistry

Abstract

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