Succinct synthesis of saturated hydroxy fatty acids and

Mads Holmgaard Kaspersen; Laura Jenkins; Julia Dunlop; Graeme Milligan; Trond Ulven

doi:10.1039/c7md00130d

Succinct synthesis of saturated hydroxy fatty acids and

Mads Holmgaard Kaspersen, Laura Jenkins, Julia Dunlop, Graeme Milligan, Trond Ulven

10 Citations (Scopus)

Abstract

Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

Original language	English
Journal	MedChemComm
Volume	8
Issue number	6
Pages (from-to)	1360-1365
Number of pages	6
ISSN	2040-2503
DOIs	https://doi.org/10.1039/c7md00130d
Publication status	Published - 2017
Externally published	Yes

Access to Document

10.1039/c7md00130d

Cite this

@article{a079e8ef65534cf3b949ca9045e3953b,

title = "Succinct synthesis of saturated hydroxy fatty acids and",

abstract = "Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.",

author = "Kaspersen, {Mads Holmgaard} and Laura Jenkins and Julia Dunlop and Graeme Milligan and Trond Ulven",

year = "2017",

doi = "10.1039/c7md00130d",

language = "English",

volume = "8",

pages = "1360--1365",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "6",

}

TY - JOUR

T1 - Succinct synthesis of saturated hydroxy fatty acids and

AU - Kaspersen, Mads Holmgaard

AU - Jenkins, Laura

AU - Dunlop, Julia

AU - Milligan, Graeme

AU - Ulven, Trond

PY - 2017

Y1 - 2017

N2 - Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

AB - Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

U2 - 10.1039/c7md00130d

DO - 10.1039/c7md00130d

M3 - Journal article

C2 - 30108848

SN - 2040-2503

VL - 8

SP - 1360

EP - 1365

JO - MedChemComm

JF - MedChemComm

IS - 6

ER -

Succinct synthesis of saturated hydroxy fatty acids and

Abstract

Access to Document

Fingerprint

Cite this