Succinct synthesis of saturated hydroxy fatty acids and

Mads Holmgaard Kaspersen; Laura Jenkins; Julia Dunlop; Graeme Milligan; Trond Ulven

doi:10.1039/c7md00130d

Succinct synthesis of saturated hydroxy fatty acids and

Mads Holmgaard Kaspersen, Laura Jenkins, Julia Dunlop, Graeme Milligan, Trond Ulven

10 Citationer (Scopus)

Abstract

Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

Originalsprog	Engelsk
Tidsskrift	MedChemComm
Vol/bind	8
Udgave nummer	6
Sider (fra-til)	1360-1365
Antal sider	6
ISSN	2040-2503
DOI	https://doi.org/10.1039/c7md00130d
Status	Udgivet - 2017
Udgivet eksternt	Ja

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10.1039/c7md00130d

Citationsformater

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title = "Succinct synthesis of saturated hydroxy fatty acids and",

abstract = "Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.",

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T1 - Succinct synthesis of saturated hydroxy fatty acids and

AU - Kaspersen, Mads Holmgaard

AU - Jenkins, Laura

AU - Dunlop, Julia

AU - Milligan, Graeme

AU - Ulven, Trond

PY - 2017

Y1 - 2017

N2 - Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

AB - Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

U2 - 10.1039/c7md00130d

DO - 10.1039/c7md00130d

M3 - Journal article

C2 - 30108848

SN - 2040-2503

VL - 8

SP - 1360

EP - 1365

JO - MedChemComm

JF - MedChemComm

IS - 6

ER -

Succinct synthesis of saturated hydroxy fatty acids and

Abstract

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