Abstract
BACKGROUND: Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico-striato-thalamic-cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS.
METHODS: This study was designed to investigate changes in gray and white matter in medication-free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods.
RESULTS AND CONCLUSION: Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well-defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS.
| Original language | English |
|---|---|
| Journal | Movement Disorders |
| Volume | 29 |
| Issue number | 9 |
| Pages (from-to) | 1212-1216 |
| Number of pages | 5 |
| ISSN | 0885-3185 |
| DOIs | |
| Publication status | Published - Aug 2014 |
Keywords
- Brain
- Brain Mapping
- Case-Control Studies
- Child
- Corpus Callosum
- Diffusion Tensor Imaging
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Tourette Syndrome