Study of medication-free children with Tourette syndrome do not show imaging abnormalities

TY - JOUR

T1 - Study of medication-free children with Tourette syndrome do not show imaging abnormalities

AU - Jeppesen, Signe Søndergaard

AU - Debes, Nanette Mol

AU - Simonsen, Helle Juhl

AU - Rostrup, Egill

AU - Larsson, H B W

AU - Skov, Liselotte

N1 - © 2014 International Parkinson and Movement Disorder Society.

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND: Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico-striato-thalamic-cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS.METHODS: This study was designed to investigate changes in gray and white matter in medication-free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods.RESULTS AND CONCLUSION: Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well-defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS.

AB - BACKGROUND: Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico-striato-thalamic-cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS.METHODS: This study was designed to investigate changes in gray and white matter in medication-free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods.RESULTS AND CONCLUSION: Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well-defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS.

KW - Brain

KW - Brain Mapping

KW - Case-Control Studies

KW - Child

KW - Corpus Callosum

KW - Diffusion Tensor Imaging

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Tourette Syndrome

U2 - 10.1002/mds.25858

DO - 10.1002/mds.25858

M3 - Journal article

C2 - 24867681

SN - 0885-3185

VL - 29

SP - 1212

EP - 1216

JO - Movement Disorders

JF - Movement Disorders

IS - 9

ER -