Abstract
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 44 |
| Issue number | 2 |
| Pages (from-to) | 237-240 |
| Number of pages | 4 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - Feb 2001 |
Keywords
- Adipose Tissue
- Adult
- Aged
- Blood Glucose
- Blood Pressure
- C-Peptide
- Denmark
- Diabetes Mellitus, Type 2
- European Continental Ancestry Group
- Exons
- Fasting
- Gene Frequency
- Humans
- Insulin
- Insulin Resistance
- Middle Aged
- Muscle, Skeletal
- PTEN Phosphohydrolase
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phosphoric Monoester Hydrolases
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational
- Tumor Suppressor Proteins
