Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

L Hansen; J N Jensen; C T Ekstrøm; H Vestergaard; T Hansen; O Pedersen; Henrik Vestergaard

doi:10.1007/s001250051605

Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

L Hansen, J N Jensen, C T Ekstrøm, H Vestergaard, T Hansen, O Pedersen, Henrik Vestergaard

17 Citationer (Scopus)

Abstract

Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	44
Udgave nummer	2
Sider (fra-til)	237-240
Antal sider	4
ISSN	0012-186X
DOI	https://doi.org/10.1007/s001250051605
Status	Udgivet - feb. 2001

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10.1007/s001250051605

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title = "Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus",

abstract = "Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.",

keywords = "Adipose Tissue, Adult, Aged, Blood Glucose, Blood Pressure, C-Peptide, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Exons, Fasting, Gene Frequency, Humans, Insulin, Insulin Resistance, Middle Aged, Muscle, Skeletal, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates, Phosphoric Monoester Hydrolases, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Polymorphism, Single-Stranded Conformational, Tumor Suppressor Proteins",

author = "L Hansen and Jensen, {J N} and Ekstr{\o}m, {C T} and H Vestergaard and T Hansen and O Pedersen and Henrik Vestergaard",

year = "2001",

month = feb,

doi = "10.1007/s001250051605",

language = "English",

volume = "44",

pages = "237--240",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "2",

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TY - JOUR

T1 - Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

AU - Hansen, L

AU - Jensen, J N

AU - Ekstrøm, C T

AU - Vestergaard, H

AU - Hansen, T

AU - Pedersen, O

AU - Vestergaard, Henrik

PY - 2001/2

Y1 - 2001/2

N2 - Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.

AB - Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.

KW - Adipose Tissue

KW - Adult

KW - Aged

KW - Blood Glucose

KW - Blood Pressure

KW - C-Peptide

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Exons

KW - Fasting

KW - Gene Frequency

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Middle Aged

KW - Muscle, Skeletal

KW - PTEN Phosphohydrolase

KW - Phosphatidylinositol 3-Kinases

KW - Phosphatidylinositol Phosphates

KW - Phosphoric Monoester Hydrolases

KW - Polymerase Chain Reaction

KW - Polymorphism, Genetic

KW - Polymorphism, Restriction Fragment Length

KW - Polymorphism, Single-Stranded Conformational

KW - Tumor Suppressor Proteins

U2 - 10.1007/s001250051605

DO - 10.1007/s001250051605

M3 - Journal article

C2 - 11270682

SN - 0012-186X

VL - 44

SP - 237

EP - 240

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus

Abstract

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