Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

J Lauenborg; P Damm; J Ek; C Glümer; T Jørgensen; K Borch-Johnsen; H Vestergaard; P Hornnes; O Pedersen; Torben Hansen

doi:10.1111/j.1464-5491.2004.01343.x

Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

J Lauenborg, P Damm, J Ek, C Glümer, T Jørgensen, K Borch-Johnsen, H Vestergaard, P Hornnes, O Pedersen, Torben Hansen

11 Citations (Scopus)

Abstract

In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.

Original language	English
Journal	Diabetic Medicine
Volume	21
Issue number	12
Pages (from-to)	1310-5
Number of pages	6
ISSN	0742-3071
DOIs	https://doi.org/10.1111/j.1464-5491.2004.01343.x
Publication status	Published - Dec 2004

Keywords

Adult
C-Peptide
Case-Control Studies
DNA-Binding Proteins
Diabetes, Gestational
Female
Glucose Tolerance Test
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha
Humans
Insulin
Islets of Langerhans
Nuclear Proteins
Polymorphism, Genetic
Pregnancy
Statistics, Nonparametric
Transcription Factors

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Lauenborg, J., Damm, P., Ek, J., Glümer, C., Jørgensen, T., Borch-Johnsen, K., Vestergaard, H., Hornnes, P., Pedersen, O., & Hansen, T. (2004). Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. Diabetic Medicine, 21(12), 1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. / Lauenborg, J; Damm, P; Ek, J et al.

In: Diabetic Medicine, Vol. 21, No. 12, 12.2004, p. 1310-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Lauenborg, J, Damm, P, Ek, J, Glümer, C, Jørgensen, T, Borch-Johnsen, K, Vestergaard, H, Hornnes, P, Pedersen, O & Hansen, T 2004, 'Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus', Diabetic Medicine, vol. 21, no. 12, pp. 1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

Lauenborg J, Damm P, Ek J, Glümer C, Jørgensen T, Borch-Johnsen K et al. Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. Diabetic Medicine. 2004 Dec;21(12):1310-5. doi: 10.1111/j.1464-5491.2004.01343.x

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abstract = "In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.",

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AU - Glümer, C

AU - Jørgensen, T

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AU - Hornnes, P

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KW - Hepatocyte Nuclear Factor 1-alpha

KW - Humans

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KW - Nuclear Proteins

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KW - Pregnancy

KW - Statistics, Nonparametric

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