Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

J Lauenborg; P Damm; J Ek; C Glümer; T Jørgensen; K Borch-Johnsen; H Vestergaard; P Hornnes; O Pedersen; Torben Hansen

doi:10.1111/j.1464-5491.2004.01343.x

Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

J Lauenborg, P Damm, J Ek, C Glümer, T Jørgensen, K Borch-Johnsen, H Vestergaard, P Hornnes, O Pedersen, Torben Hansen

11 Citationer (Scopus)

Abstract

In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.

Originalsprog	Engelsk
Tidsskrift	Diabetic Medicine
Vol/bind	21
Udgave nummer	12
Sider (fra-til)	1310-5
Antal sider	6
ISSN	0742-3071
DOI	https://doi.org/10.1111/j.1464-5491.2004.01343.x
Status	Udgivet - dec. 2004

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1111/j.1464-5491.2004.01343.x

Fingeraftryk

Dyk ned i forskningsemnerne om 'Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus'. Sammen danner de et unikt fingeraftryk.

Citationsformater

Lauenborg, J., Damm, P., Ek, J., Glümer, C., Jørgensen, T., Borch-Johnsen, K., Vestergaard, H., Hornnes, P., Pedersen, O., & Hansen, T. (2004). Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. Diabetic Medicine, 21(12), 1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. / Lauenborg, J; Damm, P; Ek, J et al.

I: Diabetic Medicine, Bind 21, Nr. 12, 12.2004, s. 1310-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Lauenborg, J, Damm, P, Ek, J, Glümer, C, Jørgensen, T, Borch-Johnsen, K, Vestergaard, H, Hornnes, P, Pedersen, O & Hansen, T 2004, 'Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus', Diabetic Medicine, bind 21, nr. 12, s. 1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

Lauenborg J, Damm P, Ek J, Glümer C, Jørgensen T, Borch-Johnsen K et al. Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. Diabetic Medicine. 2004 dec.;21(12):1310-5. doi: 10.1111/j.1464-5491.2004.01343.x

@article{c5be1aa29a574f108d376229dc8124be,

title = "Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus",

abstract = "In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.",

keywords = "Adult, C-Peptide, Case-Control Studies, DNA-Binding Proteins, Diabetes, Gestational, Female, Glucose Tolerance Test, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Humans, Insulin, Islets of Langerhans, Nuclear Proteins, Polymorphism, Genetic, Pregnancy, Statistics, Nonparametric, Transcription Factors",

author = "J Lauenborg and P Damm and J Ek and C Gl{\"u}mer and T J{\o}rgensen and K Borch-Johnsen and H Vestergaard and P Hornnes and O Pedersen and Torben Hansen",

year = "2004",

month = dec,

doi = "10.1111/j.1464-5491.2004.01343.x",

language = "English",

volume = "21",

pages = "1310--5",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

AU - Lauenborg, J

AU - Damm, P

AU - Ek, J

AU - Glümer, C

AU - Jørgensen, T

AU - Borch-Johnsen, K

AU - Vestergaard, H

AU - Hornnes, P

AU - Pedersen, O

AU - Hansen, Torben

PY - 2004/12

Y1 - 2004/12

N2 - In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.

AB - In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.

KW - Adult

KW - C-Peptide

KW - Case-Control Studies

KW - DNA-Binding Proteins

KW - Diabetes, Gestational

KW - Female

KW - Glucose Tolerance Test

KW - Hepatocyte Nuclear Factor 1

KW - Hepatocyte Nuclear Factor 1-alpha

KW - Humans

KW - Insulin

KW - Islets of Langerhans

KW - Nuclear Proteins

KW - Polymorphism, Genetic

KW - Pregnancy

KW - Statistics, Nonparametric

KW - Transcription Factors

U2 - 10.1111/j.1464-5491.2004.01343.x

DO - 10.1111/j.1464-5491.2004.01343.x

M3 - Journal article

C2 - 15569134

SN - 0742-3071

VL - 21

SP - 1310

EP - 1315

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 12

ER -