Structural ECM components in the premetastatic and metastatic niche

Anette M Høye; Janine T Erler

doi:10.1152/ajpcell.00326.2015

Structural ECM components in the premetastatic and metastatic niche

47 Citations (Scopus)

Abstract

The aim of this review is to give an overview of the extracellular matrix (ECM) components that are important for creating structural changes in the premetastatic and metastatic niche. The successful arrival and survival of cancer cells that have left the primary tumor and colonized distant sites depends on the new microenvironment they encounter. The primary tumor itself releases factors into the circulation that travel to distant organs and then initiate structural changes, both non-enzymatic and enzymatic, to create a favorable niche for the disseminating tumor cells. Therapeutic strategies aimed at targeting cell-ECM interactions may well be one of the best viable approaches to combat metastasis and thus improve patient care.

Original language	English
Article number	C955-67
Journal	A J P: Cell Physiology (Online)
Volume	310
Issue number	11
ISSN	1522-1563
DOIs	https://doi.org/10.1152/ajpcell.00326.2015
Publication status	Published - 1 Jun 2016

Keywords

Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/ajpcell.00326.2015

https://www.physiology.org/doi/pdf/10.1152/ajpcell.00326.2015

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Structural ECM components in the premetastatic and metastatic niche

Abstract

Keywords

UN SDGs

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