Structural ECM components in the premetastatic and metastatic niche

TY - JOUR

T1 - Structural ECM components in the premetastatic and metastatic niche

AU - Høye, Anette M

AU - Erler, Janine T

N1 - Copyright © 2016 the American Physiological Society.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The aim of this review is to give an overview of the extracellular matrix (ECM) components that are important for creating structural changes in the premetastatic and metastatic niche. The successful arrival and survival of cancer cells that have left the primary tumor and colonized distant sites depends on the new microenvironment they encounter. The primary tumor itself releases factors into the circulation that travel to distant organs and then initiate structural changes, both non-enzymatic and enzymatic, to create a favorable niche for the disseminating tumor cells. Therapeutic strategies aimed at targeting cell-ECM interactions may well be one of the best viable approaches to combat metastasis and thus improve patient care.

AB - The aim of this review is to give an overview of the extracellular matrix (ECM) components that are important for creating structural changes in the premetastatic and metastatic niche. The successful arrival and survival of cancer cells that have left the primary tumor and colonized distant sites depends on the new microenvironment they encounter. The primary tumor itself releases factors into the circulation that travel to distant organs and then initiate structural changes, both non-enzymatic and enzymatic, to create a favorable niche for the disseminating tumor cells. Therapeutic strategies aimed at targeting cell-ECM interactions may well be one of the best viable approaches to combat metastasis and thus improve patient care.

KW - Review

U2 - 10.1152/ajpcell.00326.2015

DO - 10.1152/ajpcell.00326.2015

M3 - Journal article

C2 - 27053524

SN - 1522-1563

VL - 310

JO - A J P: Cell Physiology (Online)

JF - A J P: Cell Physiology (Online)

IS - 11

M1 - C955-67

ER -