Abstract
Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.
| Original language | English |
|---|---|
| Journal | Cell |
| Volume | 112 |
| Issue number | 4 |
| Pages (from-to) | 535-48 |
| Number of pages | 14 |
| ISSN | 0092-8674 |
| Publication status | Published - 21 Feb 2003 |
Keywords
- Actins
- Adherens Junctions
- Animals
- Cadherins
- Cell Division
- Cytoskeleton
- Down-Regulation
- Epithelial Cells
- Epithelium
- Fungal Proteins
- GTP Phosphohydrolases
- Humans
- Microscopy, Fluorescence
- Models, Biological
- Mutation
- Phosphorylation
- Signal Transduction
- rhoA GTP-Binding Protein
- Journal Article
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
- Research Support, U.S. Gov't, P.H.S.
- Review