Sticky business: orchestrating cellular signals at adherens junctions

TY - JOUR

T1 - Sticky business

T2 - orchestrating cellular signals at adherens junctions

AU - Perez-Moreno, Mirna

AU - Jamora, Colin

AU - Fuchs, Elaine

PY - 2003/2/21

Y1 - 2003/2/21

N2 - Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.

AB - Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.

KW - Actins

KW - Adherens Junctions

KW - Animals

KW - Cadherins

KW - Cell Division

KW - Cytoskeleton

KW - Down-Regulation

KW - Epithelial Cells

KW - Epithelium

KW - Fungal Proteins

KW - GTP Phosphohydrolases

KW - Humans

KW - Microscopy, Fluorescence

KW - Models, Biological

KW - Mutation

KW - Phosphorylation

KW - Signal Transduction

KW - rhoA GTP-Binding Protein

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

KW - Research Support, U.S. Gov't, P.H.S.

KW - Review

M3 - Review

C2 - 12600316

SN - 0092-8674

VL - 112

SP - 535

EP - 548

JO - Cell

JF - Cell

IS - 4

ER -