Abstract
Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.
| Original language | English |
|---|---|
| Article number | 1247391 |
| Journal | Science (New York, N.Y.) |
| Volume | 345 |
| Issue number | 6199 |
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| ISSN | 0036-8075 |
| DOIs | |
| Publication status | Published - 22 Aug 2014 |
Keywords
- Cell Differentiation
- Cell- and Tissue-Based Therapy
- Heart Diseases
- Humans
- Muscular Diseases
- Nervous System Diseases
- Pancreatic Diseases
- Pluripotent Stem Cells
- Regeneration
- Regenerative Medicine
