Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease

TY - JOUR

T1 - Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease

AU - Fox, Ira J

AU - Daley, George Q

AU - Goldman, Steven A

AU - Huard, Johnny

AU - Kamp, Timothy J

AU - Trucco, Massimo

N1 - Copyright © 2014, American Association for the Advancement of Science.

PY - 2014/8/22

Y1 - 2014/8/22

N2 - Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.

AB - Pluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.

KW - Cell Differentiation

KW - Cell- and Tissue-Based Therapy

KW - Heart Diseases

KW - Humans

KW - Muscular Diseases

KW - Nervous System Diseases

KW - Pancreatic Diseases

KW - Pluripotent Stem Cells

KW - Regeneration

KW - Regenerative Medicine

U2 - 10.1126/science.1247391

DO - 10.1126/science.1247391

M3 - Review

C2 - 25146295

SN - 0036-8075

VL - 345

SP - 1

EP - 12

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

IS - 6199

M1 - 1247391

ER -