Abstract
BACKGROUND: Limited data suggest that statin use reduces the risk for ovarian cancer.
METHODS: Using Danish nationwide registries, we identified 4103 cases of epithelial ovarian cancer during 2000-2011 and age-matched them to 58,706 risk-set sampled controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for epithelial ovarian cancer overall, and for histological types, associated with statin use.
RESULTS: We observed a neutral association between ever use of statins and epithelial ovarian cancer risk (OR=0.98, 95% CI=0.87-1.10), and no apparent risk variation according to duration, intensity or type of statin use. Decreased ORs associated with statin use were seen for mucinous ovarian cancer (ever statin use: OR=0.63, 95% CI=0.39-1.00).
CONCLUSIONS: Statin use was not associated with overall risk for epithelial ovarian cancer. The inverse association between statin use and mucinous tumours merits further investigation.
| Original language | English |
|---|---|
| Journal | B J C |
| Volume | 112 |
| Issue number | 1 |
| Pages (from-to) | 157-61 |
| Number of pages | 5 |
| ISSN | 0007-0920 |
| DOIs | |
| Publication status | Published - 6 Jan 2015 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Denmark
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Middle Aged
- Ovarian Neoplasms
- Registries
- Risk
