Statin use and risk for ovarian cancer: a Danish nationwide case-control study

TY - JOUR

T1 - Statin use and risk for ovarian cancer

T2 - a Danish nationwide case-control study

AU - Baandrup, L

AU - Dehlendorff, C

AU - Friis, Søren

AU - Olsen, J H

AU - Kjær, S K

PY - 2015/1/6

Y1 - 2015/1/6

N2 - BACKGROUND: Limited data suggest that statin use reduces the risk for ovarian cancer.METHODS: Using Danish nationwide registries, we identified 4103 cases of epithelial ovarian cancer during 2000-2011 and age-matched them to 58,706 risk-set sampled controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for epithelial ovarian cancer overall, and for histological types, associated with statin use.RESULTS: We observed a neutral association between ever use of statins and epithelial ovarian cancer risk (OR=0.98, 95% CI=0.87-1.10), and no apparent risk variation according to duration, intensity or type of statin use. Decreased ORs associated with statin use were seen for mucinous ovarian cancer (ever statin use: OR=0.63, 95% CI=0.39-1.00).CONCLUSIONS: Statin use was not associated with overall risk for epithelial ovarian cancer. The inverse association between statin use and mucinous tumours merits further investigation.

AB - BACKGROUND: Limited data suggest that statin use reduces the risk for ovarian cancer.METHODS: Using Danish nationwide registries, we identified 4103 cases of epithelial ovarian cancer during 2000-2011 and age-matched them to 58,706 risk-set sampled controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for epithelial ovarian cancer overall, and for histological types, associated with statin use.RESULTS: We observed a neutral association between ever use of statins and epithelial ovarian cancer risk (OR=0.98, 95% CI=0.87-1.10), and no apparent risk variation according to duration, intensity or type of statin use. Decreased ORs associated with statin use were seen for mucinous ovarian cancer (ever statin use: OR=0.63, 95% CI=0.39-1.00).CONCLUSIONS: Statin use was not associated with overall risk for epithelial ovarian cancer. The inverse association between statin use and mucinous tumours merits further investigation.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Denmark

KW - Female

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Middle Aged

KW - Ovarian Neoplasms

KW - Registries

KW - Risk

U2 - 10.1038/bjc.2014.574

DO - 10.1038/bjc.2014.574

M3 - Letter

C2 - 25393364

SN - 0007-0920

VL - 112

SP - 157

EP - 161

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

IS - 1

ER -