State-Dependent Changes in Brain Glycogen Metabolism

Mauro DiNuzzo*, Anne B. Walls, Gülin Öz, Elizabeth R. Seaquist, Helle S. Waagepetersen, Lasse K. Bak, Maiken Nedergaard, Arne Schousboe

*Corresponding author af dette arbejde
    2 Citationer (Scopus)

    Abstract

    A fundamental understanding of glycogen structure, concentration, polydispersity and turnover is critical to qualify the role of glycogen in the brain. These molecular and metabolic features are under the control of neuronal activity through the interdependent action of neuromodulatory tone, ionic homeostasis and availability of metabolic substrates, all variables that concur to define the state of the system. In this chapter, we briefly describe how glycogen responds to selected behavioral, nutritional, environmental, hormonal, developmental and pathological conditions. We argue that interpreting glycogen metabolism through the lens of brain state is an effective approach to establish the relevance of energetics in connecting molecular and cellular neurophysiology to behavior.

    OriginalsprogEngelsk
    TitelBrain Glycogen Metabolism
    RedaktørerMauro DiNuzzo, Arne Schousboe
    Antal sider41
    ForlagSpringer
    Publikationsdato2019
    Sider269-309
    ISBN (Trykt)978-3-030-27479-5
    ISBN (Elektronisk)978-3-030-27480-1
    DOI
    StatusUdgivet - 2019
    NavnAdvances in Neurobiology
    Vol/bind23
    ISSN2190-5215

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