Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer

Jesper Bøje Andersen; M Aaboe; E C Borden; O G Goloubeva; B A Hassel; T F Orntoft

doi:10.1038/sj.bjc.6603099

Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer

Jesper Bøje Andersen, M Aaboe, E C Borden, O G Goloubeva, B A Hassel, T F Orntoft

63 Citations (Scopus)

Abstract

Bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote tissue invasion and metastasis. Microarray analysis was used to compare gene expression in normal bladder urothelium with that in tumours at different stages of progression. The innate immune response gene, interferon-stimulated gene 15 kDa (ISG15, GIP2), was highly expressed at all stages of bladder cancer as compared to normal urothelium. Western blotting revealed a tumour-associated expression of ISG15 protein. ISG15 exhibited a stage-associated expression, with significantly (P

Original language	English
Journal	B J C
Volume	94
Issue number	10
Pages (from-to)	1465-71
Number of pages	7
ISSN	0007-0920
DOIs	https://doi.org/10.1038/sj.bjc.6603099
Publication status	Published - 22 May 2006
Externally published	Yes

Keywords

Blotting, Western
Cell Nucleus
Cytokines
Gene Expression Profiling
Humans
Muscle Neoplasms
Neoplasm Invasiveness
Neoplasm Staging
Oligonucleotide Array Sequence Analysis
Stromal Cells
Ubiquitins
Urinary Bladder Neoplasms
Urothelium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.bjc.6603099

Cite this

@article{e4316eb516614f13b404e9b810f8936e,

title = "Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer",

abstract = "Bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote tissue invasion and metastasis. Microarray analysis was used to compare gene expression in normal bladder urothelium with that in tumours at different stages of progression. The innate immune response gene, interferon-stimulated gene 15 kDa (ISG15, GIP2), was highly expressed at all stages of bladder cancer as compared to normal urothelium. Western blotting revealed a tumour-associated expression of ISG15 protein. ISG15 exhibited a stage-associated expression, with significantly (P",

keywords = "Blotting, Western, Cell Nucleus, Cytokines, Gene Expression Profiling, Humans, Muscle Neoplasms, Neoplasm Invasiveness, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Stromal Cells, Ubiquitins, Urinary Bladder Neoplasms, Urothelium",

author = "Andersen, {Jesper B{\o}je} and M Aaboe and Borden, {E C} and Goloubeva, {O G} and Hassel, {B A} and Orntoft, {T F}",

year = "2006",

month = may,

day = "22",

doi = "10.1038/sj.bjc.6603099",

language = "English",

volume = "94",

pages = "1465--71",

journal = "The British journal of cancer. Supplement",

issn = "0007-0920",

publisher = "nature publishing group",

number = "10",

}

TY - JOUR

T1 - Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer

AU - Andersen, Jesper Bøje

AU - Aaboe, M

AU - Borden, E C

AU - Goloubeva, O G

AU - Hassel, B A

AU - Orntoft, T F

PY - 2006/5/22

Y1 - 2006/5/22

N2 - Bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote tissue invasion and metastasis. Microarray analysis was used to compare gene expression in normal bladder urothelium with that in tumours at different stages of progression. The innate immune response gene, interferon-stimulated gene 15 kDa (ISG15, GIP2), was highly expressed at all stages of bladder cancer as compared to normal urothelium. Western blotting revealed a tumour-associated expression of ISG15 protein. ISG15 exhibited a stage-associated expression, with significantly (P

AB - Bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote tissue invasion and metastasis. Microarray analysis was used to compare gene expression in normal bladder urothelium with that in tumours at different stages of progression. The innate immune response gene, interferon-stimulated gene 15 kDa (ISG15, GIP2), was highly expressed at all stages of bladder cancer as compared to normal urothelium. Western blotting revealed a tumour-associated expression of ISG15 protein. ISG15 exhibited a stage-associated expression, with significantly (P

KW - Blotting, Western

KW - Cell Nucleus

KW - Cytokines

KW - Gene Expression Profiling

KW - Humans

KW - Muscle Neoplasms

KW - Neoplasm Invasiveness

KW - Neoplasm Staging

KW - Oligonucleotide Array Sequence Analysis

KW - Stromal Cells

KW - Ubiquitins

KW - Urinary Bladder Neoplasms

KW - Urothelium

U2 - 10.1038/sj.bjc.6603099

DO - 10.1038/sj.bjc.6603099

M3 - Journal article

C2 - 16641915

SN - 0007-0920

VL - 94

SP - 1465

EP - 1471

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

IS - 10

ER -

Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this