Spontaneous regression of metastases from melanoma: review of the literature

Louise Vennegaard Kalialis; Krzysztof T Drzewiecki; Helle Klyver; Louise Vennegaard Kalialis; Krzysztof T Drzewiecki; Helle Klyver

doi:10.1097/CMR.0b013e32832eabd5

Spontaneous regression of metastases from melanoma: review of the literature

Louise Vennegaard Kalialis, Krzysztof T Drzewiecki, Helle Klyver, Louise Vennegaard Kalialis, Krzysztof T Drzewiecki, Helle Klyver

122 Citations (Scopus)

Abstract

Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.

Original language	English
Journal	Melanoma Research
Volume	19
Issue number	5
Pages (from-to)	275-82
Number of pages	8
ISSN	0960-8931
DOIs	https://doi.org/10.1097/CMR.0b013e32832eabd5 https://doi.org/10.1097/CMR.0b013e32832eabd5
Publication status	Published - 1 Oct 2009

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title = "Spontaneous regression of metastases from melanoma: review of the literature",

abstract = "Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.",

author = "Kalialis, {Louise Vennegaard} and Drzewiecki, {Krzysztof T} and Helle Klyver and Kalialis, {Louise Vennegaard} and Drzewiecki, {Krzysztof T} and Helle Klyver",

note = "Keywords: Humans; Lymphatic Metastasis; Melanoma; Neoplasm Regression, Spontaneous; Skin Neoplasms",

year = "2009",

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doi = "10.1097/CMR.0b013e32832eabd5",

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T1 - Spontaneous regression of metastases from melanoma: review of the literature

AU - Kalialis, Louise Vennegaard

AU - Drzewiecki, Krzysztof T

AU - Klyver, Helle

AU - Kalialis, Louise Vennegaard

AU - Drzewiecki, Krzysztof T

AU - Klyver, Helle

N1 - Keywords: Humans; Lymphatic Metastasis; Melanoma; Neoplasm Regression, Spontaneous; Skin Neoplasms

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.

AB - Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.

U2 - 10.1097/CMR.0b013e32832eabd5

DO - 10.1097/CMR.0b013e32832eabd5

M3 - Journal article

C2 - 19633580

SN - 0960-8931

VL - 19

SP - 275

EP - 282

JO - Melanoma Research

JF - Melanoma Research

IS - 5

ER -

Spontaneous regression of metastases from melanoma: review of the literature

Abstract

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