TY - JOUR
T1 - Spontaneous regression of metastases from melanoma: review of the literature
AU - Kalialis, Louise Vennegaard
AU - Drzewiecki, Krzysztof T
AU - Klyver, Helle
AU - Kalialis, Louise Vennegaard
AU - Drzewiecki, Krzysztof T
AU - Klyver, Helle
N1 - Keywords: Humans; Lymphatic Metastasis; Melanoma; Neoplasm Regression, Spontaneous; Skin Neoplasms
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.
AB - Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.
U2 - 10.1097/CMR.0b013e32832eabd5
DO - 10.1097/CMR.0b013e32832eabd5
M3 - Journal article
C2 - 19633580
SN - 0960-8931
VL - 19
SP - 275
EP - 282
JO - Melanoma Research
JF - Melanoma Research
IS - 5
ER -