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Spironolactone induces apoptosis and inhibits NF-kappaB independent of the mineralocorticoid receptor
Søren Ulrik Salling Sønder,
Anders Woetmann
,
Niels Odum
, Klaus Bendtzen
Functional Genomics
Cell Biology and Physiology
20
Citations (Scopus)
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Medicine & Life Sciences
Mineralocorticoid Receptors
81%
Spironolactone
80%
NF-kappa B
67%
Apoptosis
38%
Sulfasalazine
32%
Mineralocorticoid Receptor Antagonists
25%
Cytokines
11%
NF-KappaB Inhibitor alpha
11%
Eplerenone
9%
Anti-Inflammatory Agents
9%
Cytoplasmic and Nuclear Receptors
6%
Pharmaceutical Preparations
5%
Blood Cells
5%
Cell Death
4%
Transcription Factors
4%
Phosphorylation
4%
Chemical Compounds
Mineralocorticoid
100%
Spironolactone
98%
Sulfasalazine
52%
Apoptotic
27%
Antiinflammatory
15%
Eplerenone
14%
Aldosterone Antagonist
14%
Mineralocorticoid Antagonist
14%
Aldosterone
11%
Cell Death
8%
Drug
8%
Metabolite
5%