Abstract
The main objective of this thesis is to develop quantitative fluorescence-based,
spectroscopic tools for probing the 3D structure and dynamics of DNA and
RNA. The thesis is founded on six peer-reviewed papers covering mainly the
development, characterization and use of fluorescent nucleobase analogues. In
addition, four software packages is presented for the simulation and quantitative
analysis of time-resolved and steady-state UV-Vis absorption and fluorescence
experiments.
spectroscopic tools for probing the 3D structure and dynamics of DNA and
RNA. The thesis is founded on six peer-reviewed papers covering mainly the
development, characterization and use of fluorescent nucleobase analogues. In
addition, four software packages is presented for the simulation and quantitative
analysis of time-resolved and steady-state UV-Vis absorption and fluorescence
experiments.
| Original language | English |
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| Publisher | Department of Chemistry, Faculty of Science, University of Copenhagen |
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| Number of pages | 216 |
| Publication status | Published - 2012 |