Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera

I C Bygbjerg; S Jepsen; T G Theander; Niels Odum

Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera

I C Bygbjerg, S Jepsen, T G Theander, Niels Odum

21 Citations (Scopus)

Abstract

Antigens of Plasmodium falciparum, in supernatants of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with falciparum and ovale malaria; vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensitized individuals did not respond to the affinity purified antigen preparations from malaria patients' sera indicating that significant amounts of non-specific mitogens were not present.

Original language	English
Journal	Clinical and Experimental Immunology
Volume	59
Issue number	2
Pages (from-to)	421-6
Number of pages	5
ISSN	0009-9104
Publication status	Published - 1985

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Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera. / Bygbjerg, I C; Jepsen, S; Theander, T G et al.

In: Clinical and Experimental Immunology, Vol. 59, No. 2, 1985, p. 421-6.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera",

abstract = "Antigens of Plasmodium falciparum, in supernatants of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with falciparum and ovale malaria; vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensitized individuals did not respond to the affinity purified antigen preparations from malaria patients' sera indicating that significant amounts of non-specific mitogens were not present.",

author = "Bygbjerg, {I C} and S Jepsen and Theander, {T G} and Niels Odum",

note = "Keywords: Adult; Antigens, Protozoan; Cells, Cultured; Female; Humans; Immunoglobulin G; Lymphocyte Activation; Lymphocytes; Malaria; Male; Plasmodium falciparum; Solubility; Thymidine; Time Factors",

year = "1985",

language = "English",

volume = "59",

pages = "421--6",

journal = "Clinical and Experimental Immunology, Supplement",

issn = "0964-2536",

publisher = "Wiley-Blackwell",

number = "2",

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T1 - Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera

AU - Bygbjerg, I C

AU - Jepsen, S

AU - Theander, T G

AU - Odum, Niels

N1 - Keywords: Adult; Antigens, Protozoan; Cells, Cultured; Female; Humans; Immunoglobulin G; Lymphocyte Activation; Lymphocytes; Malaria; Male; Plasmodium falciparum; Solubility; Thymidine; Time Factors

PY - 1985

Y1 - 1985

N2 - Antigens of Plasmodium falciparum, in supernatants of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with falciparum and ovale malaria; vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensitized individuals did not respond to the affinity purified antigen preparations from malaria patients' sera indicating that significant amounts of non-specific mitogens were not present.

AB - Antigens of Plasmodium falciparum, in supernatants of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with falciparum and ovale malaria; vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensitized individuals did not respond to the affinity purified antigen preparations from malaria patients' sera indicating that significant amounts of non-specific mitogens were not present.

M3 - Journal article

C2 - 3884198

SN - 0964-2536

VL - 59

SP - 421

EP - 426

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

IS - 2

ER -

Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera

Abstract

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