Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients

Christian Munck; Jens Helby Petersen; Christian G. Westergaard; Celeste Porsbjerg; Vibeke Backer; Lars H. Hansen

doi:10.1371/journal.pone.0158622

Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients

Christian Munck, Jens Helby Petersen, Christian G. Westergaard, Celeste Porsbjerg, Vibeke Backer, Lars H. Hansen

Department of Clinical Medicine

15 Citations (Scopus)

Abstract

Asthma is a common disease causing cough, wheezing and shortness of breath. It has been shown that the lung microbiota in asthma patients is different from the lung microbiota in healthy controls suggesting that a connection between asthma and the lung microbiome exists. Individuals with asthma who are also tobacco smokers experience more severe asthma symptoms and smoking cessation is associated with improved asthma control. In the present study we investigated if smoking cessation in asthma patients is associated with a change in the bacterial community in the lungs, examined using induced sputum. We found that while tobacco smokers with asthma have a greater bacterial diversity in the induced sputum compared to non-smoking healthy controls, smoking cessation does not lead to a change in the microbial diversity.

Original language	English
Article number	e0158622
Journal	PloS one
Volume	11
Issue number	7
Pages (from-to)	1-11
Number of pages	11
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0158622
Publication status	Published - 8 Jul 2016

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10.1371/journal.pone.0158622Licence: CC BY

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Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients

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