Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients

Christian Munck; Jens Helby Petersen; Christian G. Westergaard; Celeste Porsbjerg; Vibeke Backer; Lars H. Hansen

doi:10.1371/journal.pone.0158622

Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients

Christian Munck, Jens Helby Petersen, Christian G. Westergaard, Celeste Porsbjerg, Vibeke Backer, Lars H. Hansen

Institut for Klinisk Medicin

15 Citationer (Scopus)

Abstract

Asthma is a common disease causing cough, wheezing and shortness of breath. It has been shown that the lung microbiota in asthma patients is different from the lung microbiota in healthy controls suggesting that a connection between asthma and the lung microbiome exists. Individuals with asthma who are also tobacco smokers experience more severe asthma symptoms and smoking cessation is associated with improved asthma control. In the present study we investigated if smoking cessation in asthma patients is associated with a change in the bacterial community in the lungs, examined using induced sputum. We found that while tobacco smokers with asthma have a greater bacterial diversity in the induced sputum compared to non-smoking healthy controls, smoking cessation does not lead to a change in the microbial diversity.

Originalsprog	Engelsk
Artikelnummer	e0158622
Tidsskrift	PloS one
Vol/bind	11
Udgave nummer	7
Sider (fra-til)	1-11
Antal sider	11
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0158622
Status	Udgivet - 8 jul. 2016

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10.1371/journal.pone.0158622Licens: CC BY

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AU - Backer, Vibeke

AU - Hansen, Lars H.

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AB - Asthma is a common disease causing cough, wheezing and shortness of breath. It has been shown that the lung microbiota in asthma patients is different from the lung microbiota in healthy controls suggesting that a connection between asthma and the lung microbiome exists. Individuals with asthma who are also tobacco smokers experience more severe asthma symptoms and smoking cessation is associated with improved asthma control. In the present study we investigated if smoking cessation in asthma patients is associated with a change in the bacterial community in the lungs, examined using induced sputum. We found that while tobacco smokers with asthma have a greater bacterial diversity in the induced sputum compared to non-smoking healthy controls, smoking cessation does not lead to a change in the microbial diversity.

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Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients

Abstract

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