Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study

Inger Christine Munch, Jakob Ek, Line Kessel, Birgit Sander, Gitte Juul Almind, Karen Brøndum-Nielsen, Allan Linneberg, Michael Larsen, Inger Christine Munch, Jakob Ek, Line Kessel, Birgit Sander, Gitte Juul Almind, Karen Brøndum-Nielsen, Allan Linneberg, Michael Larsen

29 Citations (Scopus)

Abstract

Purpose. To study associations of small, hard macular drusen and peripheral drusen with genotypes associated with agerelated macular degeneration (AMD). Methods. Digital grayscale fundus photographs recorded in red-free illumination were graded for the presence of drusen in 1107 subjects aged 30 to 66 years. Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH), in LOC387715, and in complement factor B (CFB). Results. The prevalence of 20 or more small, hard macular drusen per eye was 14%, with no association to the investigated polymorphisms. Peripheral drusen were associated with CFHY402H (odds ratio [OR], 4.3; 95% confidence interval [95% CI], 1.4 -13, for CC versus TT genotypes) as was macular drusen >63 μm (OR, 1.9; 95% CI, 1.1-3.1, for CC versus TT genotypes). Macular drusen >63 μm were associated with the presence of 20 or more small, hard macular drusen (OR, 1.7; 95% CI, 1.1-2.6) and with peripheral drusen (OR, 2.5; 95% CI,1.2-5.4) Conclusions. In this study, the presence of 20 or more small, hard macular drusen per eye was not associated with known AMD-related polymorphisms, whereas the study confirmed an association of peripheral drusen with CFHY402H.

Original languageEnglish
JournalInvestigative Ophthalmology & Visual Science
Volume51
Issue number5
Pages (from-to)2317-21
Number of pages5
ISSN0146-0404
DOIs
Publication statusPublished - 1 May 2010

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