Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

Stine D Ohlendorff; Charlotte L Tofteng; Jens-Erik B Jensen; Solveig Petersen; Roberto Civitelli; Mogens Fenger; Bo Abrahamsen; Anne P Hermann; Pia Agnete Eiken; Niklas R Jørgensen

doi:http://dx.doi.org/10.1097/FPC.0b013e3280951625

Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

Stine D Ohlendorff, Charlotte L Tofteng, Jens-Erik B Jensen, Solveig Petersen, Roberto Civitelli, Mogens Fenger, Bo Abrahamsen, Anne P Hermann, Pia Agnete Eiken, Niklas R Jørgensen

Department of Clinical Medicine

90 Citations (Scopus)

Abstract

The purinergic P2RX7 receptor (P2RX7) has been shown to play a role in the regulation of osteoblast and osteoclast activity. The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo.

Original language	English
Journal	Pharmacogenetics and Genomics
Volume	17
Issue number	7
Pages (from-to)	555-67
Number of pages	13
ISSN	1744-6872
DOIs	https://doi.org/10.1097/FPC.0b013e3280951625
Publication status	Published - 1 Jul 2007

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Ohlendorff, S. D., Tofteng, C. L., Jensen, J-E. B., Petersen, S., Civitelli, R., Fenger, M., Abrahamsen, B., Hermann, A. P., Eiken, P. A., & Jørgensen, N. R. (2007). Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment. Pharmacogenetics and Genomics, 17(7), 555-67. https://doi.org/10.1097/FPC.0b013e3280951625

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abstract = "The purinergic P2RX7 receptor (P2RX7) has been shown to play a role in the regulation of osteoblast and osteoclast activity. The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo.",

author = "Ohlendorff, {Stine D} and Tofteng, {Charlotte L} and Jensen, {Jens-Erik B} and Solveig Petersen and Roberto Civitelli and Mogens Fenger and Bo Abrahamsen and Hermann, {Anne P} and Eiken, {Pia Agnete} and J{\o}rgensen, {Niklas R}",

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T1 - Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

AU - Ohlendorff, Stine D

AU - Tofteng, Charlotte L

AU - Jensen, Jens-Erik B

AU - Petersen, Solveig

AU - Civitelli, Roberto

AU - Fenger, Mogens

AU - Abrahamsen, Bo

AU - Hermann, Anne P

AU - Eiken, Pia Agnete

AU - Jørgensen, Niklas R

PY - 2007/7/1

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N2 - The purinergic P2RX7 receptor (P2RX7) has been shown to play a role in the regulation of osteoblast and osteoclast activity. The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo.

AB - The purinergic P2RX7 receptor (P2RX7) has been shown to play a role in the regulation of osteoblast and osteoclast activity. The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo.

U2 - http://dx.doi.org/10.1097/FPC.0b013e3280951625

DO - http://dx.doi.org/10.1097/FPC.0b013e3280951625

M3 - Journal article

SN - 1744-6872

VL - 17

SP - 555

EP - 567

JO - Pharmacogenetics

JF - Pharmacogenetics

IS - 7

ER -

Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

Abstract

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