Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

Stine D Ohlendorff, Charlotte L Tofteng, Jens-Erik B Jensen, Solveig Petersen, Roberto Civitelli, Mogens Fenger, Bo Abrahamsen, Anne P Hermann, Pia Agnete Eiken, Niklas R Jørgensen

90 Citationer (Scopus)

Abstract

The purinergic P2RX7 receptor (P2RX7) has been shown to play a role in the regulation of osteoblast and osteoclast activity. The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo.
OriginalsprogEngelsk
TidsskriftPharmacogenetics and Genomics
Vol/bind17
Udgave nummer7
Sider (fra-til)555-67
Antal sider13
ISSN1744-6872
DOI
StatusUdgivet - 1 jul. 2007

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