Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

Lizhi Leng; Jiya Sun; Jinrong Huang; Fei Gong; Ling Yang; Shuoping Zhang; Xuye Yuan; Fang Fang; Xun Xu; Yonglun Luo; Lars Bolund; Brock A. Peters; Guangxiu Lu; Taijiao Jiang; Fengping Xu; Ge Lin

doi:10.1016/j.stem.2019.09.004

Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

Lizhi Leng, Jiya Sun, Jinrong Huang, Fei Gong, Ling Yang, Shuoping Zhang, Xuye Yuan, Fang Fang, Xun Xu, Yonglun Luo, Lars Bolund, Brock A. Peters, Guangxiu Lu, Taijiao Jiang, Fengping Xu, Ge Lin

Genome Research and Molecular Bio Medicine

11 Citations (Scopus)

Abstract

Leng et al. performed a comprehensive survey of transcriptional activities between biparental and uniparental embryos by single-cell RNA sequencing. They provide insights into the critical features of parental genome activation before implantation and help elucidate parent-of-origin effects in early human development.

Original language	English
Journal	Cell Stem Cell
Volume	25
Issue number	5
Pages (from-to)	697-712, e1-e6
ISSN	1934-5909
DOIs	https://doi.org/10.1016/j.stem.2019.09.004
Publication status	Published - 2019

Keywords

androgenetic embryos
biparental embryos
embryonic genome activation
maternally biased expressed genes
parent-of-origin effects
parthenogenetic embryos
paternally biased expressed genes
single-cell RNA sequencing

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10.1016/j.stem.2019.09.004

http://www.cell.com/article/S1934590919303893/pdf

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Leng, L., Sun, J., Huang, J., Gong, F., Yang, L., Zhang, S., Yuan, X., Fang, F., Xu, X., Luo, Y., Bolund, L., Peters, B. A., Lu, G., Jiang, T., Xu, F., & Lin, G. (2019). Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development. Cell Stem Cell, 25(5), 697-712, e1-e6. https://doi.org/10.1016/j.stem.2019.09.004

Leng, L, Sun, J, Huang, J, Gong, F, Yang, L, Zhang, S, Yuan, X, Fang, F, Xu, X, Luo, Y, Bolund, L, Peters, BA, Lu, G, Jiang, T, Xu, F & Lin, G 2019, 'Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development', Cell Stem Cell, vol. 25, no. 5, pp. 697-712, e1-e6. https://doi.org/10.1016/j.stem.2019.09.004

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title = "Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development",

abstract = "Leng et al. performed a comprehensive survey of transcriptional activities between biparental and uniparental embryos by single-cell RNA sequencing. They provide insights into the critical features of parental genome activation before implantation and help elucidate parent-of-origin effects in early human development.",

keywords = "androgenetic embryos, biparental embryos, embryonic genome activation, maternally biased expressed genes, parent-of-origin effects, parthenogenetic embryos, paternally biased expressed genes, single-cell RNA sequencing",

author = "Lizhi Leng and Jiya Sun and Jinrong Huang and Fei Gong and Ling Yang and Shuoping Zhang and Xuye Yuan and Fang Fang and Xun Xu and Yonglun Luo and Lars Bolund and Peters, {Brock A.} and Guangxiu Lu and Taijiao Jiang and Fengping Xu and Ge Lin",

year = "2019",

doi = "10.1016/j.stem.2019.09.004",

language = "English",

volume = "25",

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journal = "Cell Stem Cell",

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T1 - Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

AU - Leng, Lizhi

AU - Sun, Jiya

AU - Huang, Jinrong

AU - Gong, Fei

AU - Yang, Ling

AU - Zhang, Shuoping

AU - Yuan, Xuye

AU - Fang, Fang

AU - Xu, Xun

AU - Luo, Yonglun

AU - Bolund, Lars

AU - Peters, Brock A.

AU - Lu, Guangxiu

AU - Jiang, Taijiao

AU - Xu, Fengping

AU - Lin, Ge

PY - 2019

Y1 - 2019

N2 - Leng et al. performed a comprehensive survey of transcriptional activities between biparental and uniparental embryos by single-cell RNA sequencing. They provide insights into the critical features of parental genome activation before implantation and help elucidate parent-of-origin effects in early human development.

AB - Leng et al. performed a comprehensive survey of transcriptional activities between biparental and uniparental embryos by single-cell RNA sequencing. They provide insights into the critical features of parental genome activation before implantation and help elucidate parent-of-origin effects in early human development.

KW - androgenetic embryos

KW - biparental embryos

KW - embryonic genome activation

KW - maternally biased expressed genes

KW - parent-of-origin effects

KW - parthenogenetic embryos

KW - paternally biased expressed genes

KW - single-cell RNA sequencing

U2 - 10.1016/j.stem.2019.09.004

DO - 10.1016/j.stem.2019.09.004

M3 - Journal article

C2 - 31588047

AN - SCOPUS:85074290679

SN - 1934-5909

VL - 25

SP - 697-712, e1-e6

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 5

ER -

Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

Abstract

Keywords

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