Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development

Lizhi Leng, Jiya Sun, Jinrong Huang, Fei Gong, Ling Yang, Shuoping Zhang, Xuye Yuan, Fang Fang, Xun Xu, Yonglun Luo, Lars Bolund, Brock A. Peters, Guangxiu Lu, Taijiao Jiang, Fengping Xu, Ge Lin

11 Citationer (Scopus)

Abstract

Leng et al. performed a comprehensive survey of transcriptional activities between biparental and uniparental embryos by single-cell RNA sequencing. They provide insights into the critical features of parental genome activation before implantation and help elucidate parent-of-origin effects in early human development.

OriginalsprogEngelsk
TidsskriftCell Stem Cell
Vol/bind25
Udgave nummer5
Sider (fra-til)697-712, e1-e6
ISSN1934-5909
DOI
StatusUdgivet - 2019

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