Abstract
Little is known about basophil with respect to the different signaling transduction pathways involved in spontaneous, cytokine or anti-IgE induced adhesion and how this compares to IgE-dependent and IgE-independent mediator secretion. The purpose of the present study was to investigate the roles of beta1 and beta2 integrins in basophil adhesion as well as hosphatidylinositol 3-kinase (PI3K), src-kinases and extracellular signal regulated kinase (ERK) 1/2 in basophil adhesion and histamine release (HR).
| Original language | English |
|---|---|
| Journal | Chinese Medical Journal |
| Volume | 119 |
| Issue number | 2 |
| Pages (from-to) | 122-30 |
| Number of pages | 9 |
| ISSN | 0366-6999 |
| Publication status | Published - 2006 |
Keywords
- Androstadienes
- Antibodies, Anti-Idiotypic
- Antigens, CD18
- Antigens, CD29
- Basophils
- Cell Adhesion
- Extracellular Signal-Regulated MAP Kinases
- Flavonoids
- Histamine Release
- Humans
- Phosphatidylinositol 3-Kinases
- Signal Transduction