Signaling transduction pathways involved in basophil adhesion and histamine release

TY - JOUR

T1 - Signaling transduction pathways involved in basophil adhesion and histamine release

AU - Sha, Quan

AU - Poulsen, Lars K.

AU - Gerwien, Jens

AU - Ødum, Niels

AU - Skov, Per Stahl

PY - 2006

Y1 - 2006

N2 - Little is known about basophil with respect to the different signaling transduction pathways involved in spontaneous, cytokine or anti-IgE induced adhesion and how this compares to IgE-dependent and IgE-independent mediator secretion. The purpose of the present study was to investigate the roles of beta1 and beta2 integrins in basophil adhesion as well as hosphatidylinositol 3-kinase (PI3K), src-kinases and extracellular signal regulated kinase (ERK) 1/2 in basophil adhesion and histamine release (HR).

AB - Little is known about basophil with respect to the different signaling transduction pathways involved in spontaneous, cytokine or anti-IgE induced adhesion and how this compares to IgE-dependent and IgE-independent mediator secretion. The purpose of the present study was to investigate the roles of beta1 and beta2 integrins in basophil adhesion as well as hosphatidylinositol 3-kinase (PI3K), src-kinases and extracellular signal regulated kinase (ERK) 1/2 in basophil adhesion and histamine release (HR).

KW - Androstadienes

KW - Antibodies, Anti-Idiotypic

KW - Antigens, CD18

KW - Antigens, CD29

KW - Basophils

KW - Cell Adhesion

KW - Extracellular Signal-Regulated MAP Kinases

KW - Flavonoids

KW - Histamine Release

KW - Humans

KW - Phosphatidylinositol 3-Kinases

KW - Signal Transduction

M3 - Journal article

C2 - 16454994

SN - 0376-2491

VL - 119

SP - 122

EP - 130

JO - National Medical Journal of China

JF - National Medical Journal of China

IS - 2

ER -